Search for dissertations about: "peptide-membrane interactions"

Showing result 1 - 5 of 7 swedish dissertations containing the words peptide-membrane interactions.

  2. 1. Proinsulin C-peptide : membrane interactions and intracellular signaling

    Author : Zhihui Zhong; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Human renal tubular cell; intracellular signal transduction; ERK1 2; JNK; Na ; K -A TPase; G-protein coupled receptor.;

    Abstract : In the past decade, new evidence has emerged of a physiological role for C-peptide. C-peptide replacement improves renal and nerve function and augments regional blood flow in type I diabetic patients. READ MORE

  4. 2. Biophysical studies of membrane interacting peptides derived from viral and Prion proteins

    Author : Kamila Oglęcka; Astrid Gräslund; Stephen White; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Prion peptides; Doppel peptide; Influenza fusion peptides; peptide-membrane interactions; translocation; linear dichroism; circular dichroism; Biophysics; Biofysik; Biophysics; biofysik;

    Abstract : This thesis focuses on peptides derived from the Prion, Doppel and Influenza haemagglutinin proteins in the context of bilayer interactions with model membranes and live cells. The studies involve spectroscopic techniques like fluorescence, fluorescence correlation spectroscopy (FCS), circular and linear dichroism (CD and LD), confocal fluorescence microscopy and NMR. READ MORE

  5. 3. NMR Investigations of Peptide-Membrane Interactions, Modulation of Peptide-Lipid Interaction as a Switch in Signaling across the Lipid Bilayer

    Author : Sofia Unnerståle; Lena Mäler; Göran Widmalm; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; peptide-lipid interaction; membrane mimetic; NMR; biophysics; Molecular biophysics; Molekylär biofysik; biofysik; Biophysics;

    Abstract : The complexity of multi cellular organisms demands systems that facilitate communicationbetween cells. The neurons in our brains for instance are specialized in this cell-cellcommunication. READ MORE

  6. 4. Physico-Chemical Investigations of, and Characterization of Model Membranes for, Lipid-Peptide Interactions

    Author : Per Wessman; Katarina Edwards; Martin Malmsten; Michel Lafleur; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; Fysikalisk kemi; Physical Chemistry; fysikalisk kemi;

    Abstract : The main focus of this thesis is on the effects caused by α-helical peptides on liposome structure, the impact of cholesterol on the peptide-membrane interactions, and the effect of aggregate curvature on the peptide affinity. Results of the studies show that the membrane destabilizing effect of the cationic α-helical peptide melittin is modulated by cholesterol. READ MORE

  7. 5. Environmental influence on alpha-helical peptides

    Author : Ana Caballero Herrera; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MD alpha helix; C-peptide; membrane proteins; hydrogen bonds; packing; dynamics;

    Abstract : Most proteins at physiological conditions fold into a native functional three-dimensional conformation. The stability of the Native state is a balance between different interactions within the protein and with the solvent. READ MORE