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Showing result 1 - 5 of 10 swedish dissertations matching the above criteria.

  2. 1. Peptidoglycan Recognition Proteins : Major Regulators of Drosophila Immunity

    Author : Peter Mellroth; Håkan Steiner; Julien Royet; Stockholms universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Innate immunity; peptidoglycan recognition protein; PGRP; Toll; Imd; Drosophila immunity; Microbiology and immunology; Mikrobiologi och immunologi;

    Abstract : All eukaryotic organisms have an innate immune system characterized by germ-line encoded receptors and effector molecules, which mediate detection and clearance of microbes such as bacteria, fungi, and parasites. VertebrateDrosophila as a genetically tractable organism with a This thesis concerns the peptidoglycan recognition protein (PGRP) gene family in the fruit fly. READ MORE

  4. 2. Peptidoglycan recognition proteins in Drosophila melanogaster

    Author : Thomas Werner; Dan Hultmark; Bruno Lemaitre; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Drosophila; PGRP; peptidoglycan; pattern recognition; imd; Relish; isoform; RNAi; mbn-2; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : The fruit fly Drosophila melanogaster is an excellent model organism to study the innate immune response, because insects and mammals share conserved features regarding the recognition and destruction of microorganisms and Drosophila is easily accessible to genetic manipulation. In my present study, I identified a new family of pattern recognition molecules for bacterial peptidoglycan in Drosophila, the Peptidoglycan Recognition Proteins (PGRP). READ MORE

  5. 3. Innate Immune Proteins in a Crustacean Pacifastacus leniusculus

    Author : Chenglin Wu; Irene Söderhäll; petr Kopácek; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2-DE; hematopoiesis; marker protein; melaniztion inhibiting protein; proPO-system; pattern recognition protein; PGN; ficolin-like protein; Immunology; Immunologi; Biology with specialization in Comparative Physiology; Biologi med inriktning mot jämförande fysiologi;

    Abstract : Hemocytes (blood cells) are important in the immune defense against pathogens in invertebrates. In crusteacean, the hemocytes and plasma components mount a strong innate immune response against different pathogens including bacteria and virus. READ MORE

  6. 4. Vesicle-mediated and free soluble delivery of bacterial effector proteins by oral and systemic pathogens

    Author : Bernard Thay; Jan Oscarsson; Mikael Rhen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Periodontitis; Aggregatibacter actinomycetemcomitans; Staphylococcus aureus; membrane vesicles; vesicle-host cell interaction; protein delivery; molekylärbiologi; Molecular Biology;

    Abstract : Periodontitis, the primary cause of tooth-loss worldwide, is a bacterially induced chronic inflammatory disease of the periodontium. It is associated with systemic conditions such as cardiovascular disease (CVD). However, pathogenic mechanisms of periodontitis-associated bacteria that may contribute to the CVD association are unclear. READ MORE

  7. 5. Identification and characterisation of five innate immune genes in the cabbage looper Trichoplusia ni

    Author : Annika Lundström; Lage Cerenius; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mikrobiologi; Microbiology;

    Abstract : When insects are infected with bacteria, they respond by producing a range of different antibacterial peptides and by activating protease cascades leading to coagulation and melanisation. Cellular defence mechanisms are also involved in killing of microorganisms through phagocytosis and encapsulation. READ MORE