Search for dissertations about: "peptidomimetic"
Showing result 11 - 15 of 18 swedish dissertations containing the word peptidomimetic.
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11. Computational prediction of ligand binding in peptide G-protein coupled receptors
Abstract : G-protein coupled receptors (GPCRs) are a superfamily of membrane receptors involved in a wide variety of biological processes, and their malfunction is associated with many diseases. Consequently, GPCRs are targeted by one-third of the drugs on the market, and constitute the focus of active public and private research in the search of more effective drugs. READ MORE
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12. Development of 2-Pyridone-based central fragments : Affecting the aggregation of amyloid proteins
Abstract : There are many applications of small organic compounds, e.g. as drugs or as tools to study biological systems. Once a compound with interesting biological activity has been found, medicinal chemists typically synthesize small libraries of compounds with systematic differences to the initial “hit” compound. READ MORE
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13. Design and synthesis of -turn peptidomimetics : Applications to angiotensin II
Abstract : This study addresses the issue of how to convert peptides into drug-like non-peptides while retaining the biological activity at peptide receptors. Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, Ang II) was used as a model peptide. Small bioactive peptides are in most cases conformationally flexible molecules. READ MORE
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14. Photoswitchable Peptidomimetics : Synthesis and Photomodulation of Functional Peptides
Abstract : The secondary structure of peptides is of pivotal importance for their biological function. The introduction of photoswitchable moieties into the backbones of peptides provides a unique way of regulating their conformation using an external stimulus, i.e., light. READ MORE
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15. Characterization of HCV Protease Inhibitors : Inhibition and Interaction Studies with Applications for Drug Discovery
Abstract : In this thesis, different approaches based on inhibition and interactions studies, have been used to characterize inhibitors of the non-structural protein 3 (NS3) from the hepatitis C virus (HCV). This involves identification of enzyme inhibitory effects and characterization of interaction mechanisms and kinetics, as well as effects on replication in a cell based system and serum protein binding. READ MORE