Search for dissertations about: "perforin"

Showing result 1 - 5 of 45 swedish dissertations containing the word perforin.

  1. 1. Islet xenotransplantation : An immunological study in the pig-to-mouse model

    Author : Birgitta Benda; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; xenotransplantation; porcine; islet; in vivo; knock-out mouse; immunohistochemistry; CsA; MDL 201; 449A; Ig; FcR; IL-6; perforin; granzyme B; macrophage; eosinophilic granulocyte; T cell; TCR; IFN- g; TNF- a; IL-2; Onkologi; Oncology; Onkologi; Clinical Immunology; klinisk immunologi;

    Abstract : Successful clinical xenotransplantation, i.e., transplantation between species, would eliminate the shortage of donor organs. In order to study the acute cellular rejection reaction following discordant xenogeneic transplantation, an experimental pig-to- mouse islet xenotransplantation model was established. READ MORE

  2. 2. Immune dysregulation in HIV-1 infected lymphoid tissue

    Author : Homira Behbahani; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; HIV-1; HAART; cytokines; chemokines; lymphoid tissue; perforin; Nef; LIF; placenta; chemokine receptor;

    Abstract : Lymphoid compartments are major sites for HIV- 1 replication. We evaluated cytokines, chemokines and immunological effector function at the single cell level in lymphoid tissues in chronically HIV-1 infected patients. READ MORE

  3. 3. Modulation of tumor sensitivity to effector mechanisms of cytotoxic lymphocytes

    Author : Kristian Hallermalm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Tumor escape; cytotoxic lymphocytes; interferon-gamma; TNF-alpha; granzyme B; Perforin; Fas ligand;

    Abstract : Today, ample evidence demonstrates a clear role for the immune system in the battle against cancer. However, the relatively high rate of mutation and proliferation of tumor cells, in combination with the selective pressure exerted by the immune system, can potentially lead to the generation of genetically altered tumor cells, which are able to evade recognition by the immune system and continue to grow and form tumors. READ MORE

  4. 4. On the immunopathogenesis of HIV infection

    Author : Jakob Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Human Immunodeficiency Virus-1; Lymphoid tissue; cell mediated immunity; CD8 T-cells; perforin; cytotoxicity; regulatory T-cells; FOXP3;

    Abstract : CD8+ T-cell dependent clearance of microbial infections by perforin mediated killing of infected cells is a central component in the combat against viral infections. In HIV- 1 infected individuals the incidence of virus infected cells in lymphoid tissue, which is the major site for virus production, does not drop, but instead slowly increases as the disease progresses. READ MORE

  5. 5. Characterisation of CD8 T cells in mucosa associated lymphoid tissue : Implications for immune control of HIV-1 infection

    Author : Máire Quigley; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; CD8 T cells; Human Immunodeficiency Virus-1; Mucosa Associated Lymphoid Tissue; perforin; cytotoxicity; gastrointestinal mucosa; tonsil; CD7 expression; Simian Immunodeficiency Virus.;

    Abstract : The role of CD8 T cells has been implicated in the partial immune control of HIV-1 infection. Ultimately these cells fail to control the infection and immune deficiency ensues in the absence of antiretroviral therapy. READ MORE