Search for dissertations about: "perfused-forearm model"
Showing result 1 - 5 of 7 swedish dissertations containing the words perfused-forearm model.
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1. Endogenous tissue-type plasminogen activator andendothelial function in vivo. A clinical perspective
Abstract : Endogenous fibrinolysis is initiated by the glycoprotein tissue-type plasminogen activator (tPA), which is released from the vascular endothelium. Plasminogen activator inhibitor type 1 (PAI-1) is the main inhibitor of tPA. READ MORE
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2. Epigenetic influence on cardiovascular protective mechanisms in vivo: explorations of t-PA release and extracellular vesicle genetic content
Abstract : ABSTRACT Background: Ischemic heart disease is one of the leading causes of death globally. This thesis explores endogenous mechanisms protecting against myocardial ischemia in context of epigenetics (changes in gene activity not caused by changes in DNA sequences). READ MORE
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3. Blood Pressure Elevation - Impact on Cardiovascular Structure and Endogenous Fibrinolysis
Abstract : Blood pressure elevation is a major risk factor for cardiovascular events and the risk increases in a dose-dependant manner. It is of importance to identify subjects prone to develop hypertension and adverse cardiovascular remodeling in order to start treatment timely. READ MORE
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4. Local regulation of the endogenous fibrinolytic system in man
Abstract : The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (tPA). The endothelium synthesises and stores tPA and regulated release of the enzyme is an important mechanism for removal of fibrin from blood vessels. Plasminogen activator inhibitor type-1 (PAI-1) is the main inhibitor of tPA. READ MORE
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5. Impairment of Endothelial Thromboprotective Function by Haemodynamic and Inflammatory Stress - Implications for hypertensive disease
Abstract : The physiologically most important activator of intravascular fibrinolysis is tissue-type plasminogen activator (t-PA). The endothelium synthesizes and stores t-PA and regulated release of the enzyme is an important local protective response to prevent thrombus extension. READ MORE