Search for dissertations about: "pericytes"
Showing result 6 - 10 of 59 swedish dissertations containing the word pericytes.
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6. Pericyte Influence on Drug Delivery Across the Blood-Brain Barrier : Implications for Therapy of Neurodegenerative Diseases
Abstract : The blood-brain barrier (BBB) represents a complex interface between the brain parenchyma and systemic blood circulation, strictly controlling exchange of substances between the two sites. Pericytes are mural cells located on the abluminal membrane of the brain endothelium, involved in BBB formation and maintenance. READ MORE
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7. Conditional targeting of the PDGF-B gene
Abstract : Platelet derived growth factors (PDGF) are known as mitogens for fibroblasts, smooth muscle cells (SMC) and glia cells in culture. Previous in vivo analyses have shown that PDGF-B is necessary for normal embryonic development and life after birth, but the relative importance of the various cellular sources of PDGF-B during development has not been clarified. READ MORE
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8. Leukocytes in Angiogenesis : Learning from Transplanted Pancreatic Islets
Abstract : Angiogenesis, the growth of new blood vessels, is a complex process involving several cell types and molecular signals. Excessive vascular growth is a problem in tumors, and insufficient vascularization hampers the function of transplanted insulin-producing pancreatic islets. READ MORE
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9. The functional role of neural cell adhesion molecule in pathological angiogenesis
Abstract : .... READ MORE
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10. Studies of PDGF receptor signaling in vitro and in vivo
Abstract : Platelet-derived growth factor receptor (PDGFR) signaling is essential for proliferation, migration and survival of cells of mesenchymal origin; however, its deregulation has been associated with various diseases, including cancer. The aim of this thesis was to clarify the molecular mechanisms of PDGFR signaling regulation. READ MORE