Search for dissertations about: "perlecan"

Showing result 1 - 5 of 17 swedish dissertations containing the word perlecan.

  2. 1. Perlecan in vascular disease

    Author : Tran Phan Kiet; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Perlecan; heparan sulfate; smooth muscle cells; intimal hyperplasia; vascular disease; atherosclerosis; restenosis; heparin-binding growth factor.;

    Abstract : Atherosclerosis has become the most common cause of death in the world. The development of the disease involves accumulation of lipids in the inner layer of the vessel wall, the intima, and recruitment of inflammatory cells and smooth muscle cells (SMCs). READ MORE

  4. 2. Basement membrane components in the chondrocyte extracellular matrix

    Author : Alexander Kvist; Lunds universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skelett; rheumatology locomotion; nidogen; chondroitin sulfate; collagen assembly; Skeleton; muscle system; type IV collagen; laminin; perlecan; basement membranes; ECM; chondrcytes; muskelsystem; reumatologi;

    Abstract : The extracellular matrix (ECM) is a network of macromolecules which, together with cells, forms the various tissues of all metazoan organisms. Cartilage, in contrast to most other tissues, contains relatively few cells in proportion to the volume occupied by ECM. READ MORE

  5. 3. The role of stroma-derived substances in breast cancer progression and their function as tumour markers

    Author : Malin Jansson; Malin Sund; Daniel Öhlund; Ola Billing; Emma Niméus; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; perlecan; type IV collagen; type I collagen; extracellular matrix; tumour biomarkers; Surgery; kirurgi;

    Abstract : Background: In 2020, more than 2,260,000 women were diagnosed with breast cancer. Most patients are cured with surgery and adjuvant treatment, but despite that, approximately 700,000 women die of the disease every year. The historical focus on breast cancer progression has been on the malignant epithelial cell. READ MORE

  6. 4. Cartilage homeostasis: Modulation of cells and extracelllar matrix assembly

    Author : Anna Johnson; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; COMP; Perlecan; chondroadherin; cartilage; ECM; Medicin människa och djur ;

    Abstract : The cartilage extracellular matrix consists of the collagen network which enmeshes the large aggregating proteoglycan, aggrecan. Accessory molecules regulate the formation and maintenance of these structures. This thesis studies aspects of cartilage assembly during development and its degradation in disease, focusing on the collagen network. READ MORE

  7. 5. Structure and Interactions of the Extracellular Matrix Protein PRELP

    Author : Eva Bengtsson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reumatologi; muskelsystem; Skelett; extracellular matrix; PRELP; heparin; heparan sulfate; perlecan; collagen; cell-binding; Skeleton; rheumatology locomotion; muscle system; Biochemistry; Metabolism; Biokemi;

    Abstract : This thesis describes the structure and interactions of a novel extracellular matrix protein - PRELP (proline arginine-rich end leucine-rich repeat protein). The amino acid sequence of PRELP showed that it belonged to the leucine-rich repeat (LRR) protein family in connective tissues. READ MORE