Search for dissertations about: "peroxiredoxins"
Showing result 1 - 5 of 6 swedish dissertations containing the word peroxiredoxins.
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1. Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae
Abstract : Proteins are continuously synthesized and degraded to meet the demands of the cell. Hence, a proper balance between synthesis, folding, disaggregation and degradation is of essence to ensure cell survival. Disruption of any part of this proteostasis network may have severe consequences for cellular fitness and longevity. READ MORE
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2. On chaperone co-operation in temporal and spatial protein quality control
Abstract : In order for a protein to be able to function correctly it needs to adopt its proper fold. Because of this, protein quality control (PQC) is vital at every level of cellular function. The central protein in PQC networks across all kingdoms of life are the Hsp70 molecular chaperones. READ MORE
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3. Proteostasis and Aging in Saccharomyces cerevisiae - The role of a Peroxiredoxin
Abstract : Aging is characterized by a progressive decline in physiological functions that limits biological processes, increases the risk of disease, and ultimately leads to death. At the cellular level, aging is associated with accumulation of damaged components, including proteins, indicating that protein homeostasis (or proteostasis) fails to maintain the integrity and functionality of the proteome as cells age. READ MORE
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4. Peroxiredoxins in Redox Signaling and Aging
Abstract : Peroxiredoxins have emerged as conserved modulators of the rate of aging in yeast and multicellular organisms and play a role in lifespan extension through the anti-aging intervention caloric restriction. Yet, it is not clear through what mechanism peroxiredoxins extend lifespan. READ MORE
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5. Illumination in single cell optical microscopy studies - friend and foe
Abstract : This thesis focuses on how to use light as a biological stress factor in optical microscopy experiments and simultaneously use the illumination to image the spatial and temporal protein dynamics in single yeast cells. The stress responses to environmental changes other than light have been extensively investigated in budding yeast, Saccharomyces cerevisiae, often using techniques based on population averages. READ MORE