Search for dissertations about: "phage display antibodies"

Showing result 1 - 5 of 54 swedish dissertations containing the words phage display antibodies.

2. 1. Selection and design in antibody phage display

   Author : Jonas Persson; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; specificity fine-tuning.; phage display; MUC1; automated selection; antigenicity; antibody; affinity maturation;

   Abstract : The immune system is an important part of the physiology of higher organisms. In the immune system antibodies play a key role in neutralizing and clearing potentially lethal threats from the environment. The importance of antibodies in the immune system has made them come to the attention as a tool in chemistry and medicine. READ MORE

4. 2. Molecular Recognition in Antibody Engineering. Studies on recombinant and phage displayed antibodies

   Author : Ann-Christin Malmborg Hager; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; affinity; antibody; kinetic; Immunologi; serologi; serology; Immunology; Bioteknik; Biotechnology; library; selection; surface display; phage display; association rate; dissociation rate;

   Abstract : In vitro generation of antibody fragments of desired specificity and affinity plays an important role since it permits the generation of reagents which may be valuable for diagnostic and therapeutic applications. Furthermore, the kinetic parameters for an antibody-antigen interaction, rather than the affinity, has shown to correlate with biological functions like virus neutralization. READ MORE

5. 3. Ribosome display for selection and evolution of affibody molecules

   Author : Sebastian Grimm; Per-Åke Nygren; Mike Taussig; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; ribosome display; phage display; combinatorial protein engineering; library; murine IgG1; SATB1; Ras; Raf; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

   Abstract : Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. READ MORE

6. 4. Recombinant Antibodies – Tools for building proteomic platforms

   Author : Anna Säll; Institutionen för immunteknologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibody development; recombinant scFv antibodies; phage display; affinity proteomics; mass spectrometry;

   Abstract : This thesis, which is based on four original papers, covers different aspects of the evolvement and development of proteomic platforms and the construction of human synthetic antibody libraries for the isolation of antibody reagents has been very central. There is an accelerating need for technologies capable of providing proteomic analysis of high sensitivity with good accuracy and an overall broad coverage as well as for biomarker validation. READ MORE

7. 5. Discovery of targets for tumor immunotherapy using phage display technology

   Author : Jesper Tordsson; Immunologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; serology; Immunology; colon cancer; melanoma; tumor immunotherapy; phage display; scFv; Immunologi; serologi; Cytology; oncology; cancerology; Cytologi; onkologi; cancer;

   Abstract : This thesis has focused on the development of methods and their applications for the identification of antibodies reactive with tumor associated antigens (TAA). The phage display technology provides a powerful mean to generate antibodies potentially useful for tumor immunotherapy. READ MORE