Search for dissertations about: "pharmaceutical compounds"
Showing result 16 - 20 of 202 swedish dissertations containing the words pharmaceutical compounds.
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16. Assay of catecholamines and related compounds in biological samples : with emphasis on liquid chromatography and electrochemical detection
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17. Potentiometric titration of ionizable compounds in two-phase systems
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18. Modelling and prediction of drug transport processes with experimental and calculated molecular properties : A multivariate approach
Abstract : Less than 2% of the lead compounds generated by the pharmaceutical industry enter the exploratory drug-development phase, from which point they stand only a 10% chance of becoming a commercial medicine. A large proportion of the compounds fail due to poor biopharmaceutical properties, such as permeability and solubility. READ MORE
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19. Predicting oral performance of lipid-based formulations using in vitro methods
Abstract : Oral administration of drugs is widely considered preferable to other methods by end-users and healthcare providers alike; however, not all drug compounds are inherently suited for it because some molecules are not well-absorbed by the intestine. Good absorption requires both dissolution and permeation. READ MORE
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20. Experimental and Computational Predictions of Drug Solubility in Human Gastrointestinal Fluids
Abstract : The aqueous solubility of a drug is viewed as a pivotal property for its oral absorption since only dissolved molecules can permeate the gut wall and reach the systemic circulation. The fluids in the intestine, however, do not only consist of water and therefore poor water solubility may not necessarily imply a poor solubility in the intestinal fluids and resulting low bioavailability. READ MORE