Search for dissertations about: "pharmaceutical excipients"

Showing result 1 - 5 of 24 swedish dissertations containing the words pharmaceutical excipients.

  2. 1. Pharmaceutical Nanocomposites : Structure–Mobility–Functionality Relationships in the Amorphous State

    Author : Joel Hellrup; Denny Mahlin; Göran Alderborn; László Fábián; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amorphous; pharmaceutical composites; solid state; structure; molecular mobility; spray-drying; freeze-drying; moisture sorption; physical stability; compression; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Amorphous materials are found in pharmaceutical formulations both as excipients and active ingredients. Indeed, these formulations are becoming an essential strategy for incorporating drugs into well-performing solid dosage forms. READ MORE

  4. 2. Design of solid dosage forms for mucosal vaccination - Investigations on the influence of excipients on product performance

    Author : Annika Borde; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; hydrophilic matrix tablets; osmotic pressure; protein release; freeze-drying; Vibrio cholerae; mucoadhesion; Bradford Assay; sublingual vaccine tablet; mucosal vaccination;

    Abstract : Most vaccines today are liquid formulations for parental administration. However, there are several drawbacks connected to these vaccines. Since injectable vaccines only induce systemic antibody responses, they are not effective against the various pathogens that affect mucosal surfaces with poor permeability for serum-derived antibodies, e.g. READ MORE

  5. 3. Process-induced disorder of pharmaceutical materials : Mechanisms and quantification of disorder

    Author : Samaneh Pazesh; Göran Alderborn; Jonas Berggren; Niklas Sandler; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Milling; Comminution; Powder flow; Amorphisation; Raman spectroscopy; Atomic force microscopy; Plastic stiffness; Elastic stiffness; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : One of the most important prerequisites in the drug development is to attain a reproducible and robust product in terms of its nature, and its chemical and physical properties. This can be challenging, since the crystalline form of drugs and excipients can be directly transformed into the amorphous one during normal pharmaceutical processing, referred to as process-induced amorphisation or process-induced disorder. READ MORE

  6. 4. Pharmaceutical cocrystals : formation mechanisms, solubility behaviour and solid-state properties

    Author : Amjad Alhalaweh; Peter York; Luleå tekniska universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; crystal engineering; cocrystal; formation; solubility; pH; dissolution; surface properties; solid-state properties; Health Science; Hälsovetenskap;

    Abstract : The primary aim of pharmaceutical materials engineering is the successful formulation and process development of pharmaceutical products. The diversity of solid forms available offers attractive opportunities for tailoring material properties. READ MORE

  7. 5. Biopharmaceutical aspects of intestinal drug absorption : Regional permeability and absorption-modifying excipients

    Author : David Dahlgren; Hans Lennernäs; Erik Sjögren; Bertil Abrahamsson; Christer Tannergren; Steffansen Bente; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestinal permeability; absorption-modifying excipients; Biofarmaci; Biopharmaceutics;

    Abstract : Before an orally administered drug reaches the systemic circulation, it has to dissolve in the intestinal fluids, permeate across the intestinal epithelial cell barrier, and pass through the liver. The permeation rate of drug compounds can be low and show regional differences.The thesis had two general aims. READ MORE