Search for dissertations about: "pharmaceutical process validation"

Showing result 1 - 5 of 12 swedish dissertations containing the words pharmaceutical process validation.

  2. 1. Confidence Predictions in Pharmaceutical Sciences

    Author : Staffan Arvidsson McShane; Ola Spjuth; Wesley Schaal; Lars Carlsson; Ernst Ahlberg; Stefan Kramer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; machine learning; QSAR; Conformal prediction; Venn-ABERS; Probabilistic machine learning; Machine learning; Maskininlärning; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The main focus of this thesis has been on Quantitative Structure Activity Relationship (QSAR) modeling using methods producing valid measures of uncertainty. The goal of QSAR is to prospectively predict the outcome from assays, such as ADMET (Absorption, Distribution, Metabolism, Excretion), toxicity and on- and off-target interactions, for novel compounds. READ MORE

  4. 2. A supercritical fluids extraction process for the production of drug loaded biodegradable microparticles

    Author : Raouf Ghaderi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : The purpose of this thesis was to develop methods suitable for the incorporation of drug substancessuch as proteins into microparticles intended for controlled release. In particular a novel techniquefor the preparation of microparticles using supercritical fluids was investigated. READ MORE

  5. 3. Change in the Pharmaceutical Industry : Aspects on Innovation, Entrepreneurship, Openness, and Decision Making

    Author : Thomas Hedner; Magnus Klofsten; Johan Braet; Mirjam Knockaert; Linköpings universitet; []
    Keywords : Pharmaceutical industry; Big Pharma; life sciences; drug discovery; drug development; R D; business model; innovation; closed innovation; open innovation; entrepreneurship; intellectual property; multiple stakeholders; decision making; judgment; uncertainty; go no-go; go no-go recycle; company; SME.; Läkemedelsindustri; Big Pharma; biovetenskap; läkemedelsutveckling; utveckling av läkemedel; FoU; affärsmodell; innovation; stängd innovation; öppen innovation; entreprenörskap; immaterialrätt; beslutsfattande; osäkerhet; go no-go; go no-go recycle; företag; små och medelstora företag;

    Abstract : Over the past century, the pharmaceutical industry has been a major contributor of individual and population health and societal wealth. Its products and services have contributed to longevity of large groups of patients and symptom relief from major diseases. READ MORE

  6. 4. Fluid Dynamics and Granular Growth in High Shear Wet Granulation

    Author : Anders Darelius; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Coalescence kernel; Frictional Stress Models; Laser Doppler Anemometry; Population balances; CFD; EFD; High shear granulation; High speed imaging; Multi-dimensional; Multiphase flows;

    Abstract : High shear wet granulation is a key step in the manufacturing of tablets in the pharmaceutical industry. From the pharmaceutical industry’s point of view, there is a desire for predictive quantitative process models to be able to make in-silico process and scale-up simulations, which would shorten and reduce the cost of technology transfer from laboratory scale to manufacturing scale in drug development. READ MORE

  7. 5. Parameter estimation in heterogeneous catalysis

    Author : Jonas Sjöblom; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; microkinetic modelling; Jacobian; Parameter estimation; Latent Variable models; Design of experiments; heterogeneous catalysis; sensitivity analysis; Experimental design;

    Abstract : The detailed modelling of heterogeneous catalytic systems is challenging due to the unknown nature of new catalytic materials as well as the often required transient nature of the resulting models. Thus, this thesis deals with the methodologies involved in the kinetic modelling of heterogeneous catalysis and in particular NOx reduction systems. READ MORE