Search for dissertations about: "pharmaceutical"

Showing result 1 - 5 of 1019 swedish dissertations containing the word pharmaceutical.

  1. 1. Pharmaceutical Nanocomposites Structure–Mobility–Functionality Relationships in the Amorphous State

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Joel Hellrup; Uppsala universitet.; [2016]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amorphous; pharmaceutical composites; solid state; structure; molecular mobility; spray-drying; freeze-drying; moisture sorption; physical stability; compression; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Amorphous materials are found in pharmaceutical formulations both as excipients and active ingredients. Indeed, these formulations are becoming an essential strategy for incorporating drugs into well-performing solid dosage forms. READ MORE

  2. 2. Process-induced disorder of pharmaceutical materials Mechanisms and quantification of disorder

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Samaneh Pazesh; Uppsala universitet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Milling; Comminution; Powder flow; Amorphisation; Raman spectroscopy; Atomic force microscopy; Plastic stiffness; Elastic stiffness; Pharmaceutical Science; Farmaceutisk vetenskap;

    Abstract : One of the most important prerequisites in the drug development is to attain a reproducible and robust product in terms of its nature, and its chemical and physical properties. This can be challenging, since the crystalline form of drugs and excipients can be directly transformed into the amorphous one during normal pharmaceutical processing, referred to as process-induced amorphisation or process-induced disorder. READ MORE

  3. 3. Preparation of Pharmaceutical Powders using Supercritical Fluid Technology Pharmaceutical Applications and Physicochemical Characterisation of Powders

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sitaram P. Velaga; Uppsala universitet.; [2004]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY Pharmaceutics; FARMACI Galenisk farmaci; Pharmaceutics; Supercritical fluid; Gas Anti-Solvent; SEDS; Crystallisation; Particle design; Polymorphs; Dry powder inhalation; Solid-state behaviour; Therapeutic proteins; Precipitation; Stability; Recombinant human growth hormone hGH ; Galenisk farmaci;

    Abstract : The main aim of the thesis was to explore the potential of supercritical fluid (SF) techniques in the field of drug delivery. In particular, the relatively recently developed solution-enhanced dispersion by supercritical fluids (SEDS) technology has been employed in the preparation of particles/powders. READ MORE

  4. 4. Design of solid dosage forms for mucosal vaccination - Investigations on the influence of excipients on product performance

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Annika Borde; [2012]
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; sublingual vaccine tablet; freeze-drying; mucosal vaccination; osmotic pressure; Vibrio cholerae; hydrophilic matrix tablets; Bradford Assay; protein release; mucoadhesion;

    Abstract : Most vaccines today are liquid formulations for parental administration. However, there are several drawbacks connected to these vaccines. Since injectable vaccines only induce systemic antibody responses, they are not effective against the various pathogens that affect mucosal surfaces with poor permeability for serum-derived antibodies, e.g. READ MORE

  5. 5. Cytochrome P450 Enzymes in Bile Acid Biosynthesis and Fatty Acid Metabolism Studies on Members of the Porcine CYP4A and CYP8B Subfamilies

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Kerstin Lundell; Uppsala universitet.; [2003]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; cytochrome P450; bile acids; fatty acids; CYP4A; CYP8B; genome; porcine; hyocholic acid; Farmaceutisk biokemi; PHARMACY Pharmaceutical biochemistry; FARMACI Farmaceutisk biokemi; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Abstract : The present investigation is devoted to studies on porcine members of the cytochrome P450 4A (CYP4A) and CYP8B1 subfamilies, which are involved in bile acid biosynthesis and fatty acid metabolism. Hyocholic acid is considered to fulfil the requirements for trihydroxy bile acids in the domestic pig (Sus scrofa) in the absence of cholic acid. READ MORE