Search for dissertations about: "pharmaceutics thesis"

Showing result 1 - 5 of 66 swedish dissertations containing the words pharmaceutics thesis.

  2. 1. Intestinal barriers to oral drug absorption: Cytochrome P450 3A and ABC-transport proteins

    Author : Helena Engman; Per Artursson; Hans Lenernäs; Heyo K Kroemer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; oral drug delivery; bioavailability; human jejunum; Caco-2; ABC-transporter; P-glycoprotein; CYP3A; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : The subject of this thesis was to study two intestinal barriers to oral drug bioavailability, drug efflux proteins of the ABC-transporter family, and in particular ABCB1/P-glycoprotein (Pgp), and the drug metabolizing enzyme cytochrome P450 (CYP) 3A4. At the onset of this thesis, similarities between CYP3A4 and Pgp in terms of their tissue distribution and gene regulation, along with overlapping substrate specificities, had generated the hypothesis that CYP3A4 and Pgp may have a complementary function and thus form a coordinated intestinal barrier to drug absorption and gut wall metabolism. READ MORE

  4. 2. Drug transport and metabolism in in vitro models of the human intestine : By Shamsi D. Raeissi

    Author : Shamsi D. Raeissi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Abstract : The objective of this thesis was to study the mechanisms of drug transport and metabolism in two different in vitro models of the human intestine: monolayers of human intestinal epithelial cell lines and intestinal microsomes. The first part of the thesis shows that Caco-2 cell monolayers are a good model for mechanistic studies of drug transport. READ MORE

  5. 3. Interindividual Variability of Drug Transport Proteins : Focus on Intestinal Pgp (ABCB1) and BCRP (ABCG2)

    Author : Gunilla Englund; Per Artursson; Håkan Melhus; Andreas Kindmark; Joseph W Polli; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; membrane transport proteins; ATP-Binding Cassette Transporters; P-glycoprotein; Breast Cancer Resistance Protein; Interindividual variability; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : The appearance of adverse drug reactions is a common reason for hospitalization in Western countries. Research on underlying biological mechanisms for interindividual variability in drug response aims to better identify patients with exceptional genetic traits, disease conditions or risk of drug-drug interactions and thereby help to prevent adverse drug reactions. READ MORE

  6. 4. Flow and Compression of Granulated Powders : The Accuracy of Discrete Element Simulations and Assessment of Tablet Microstructure

    Author : Ann-Sofie Persson; Göran Frenning; Göran Alderborn; Marie Wahlgren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Discrete Element Method; Granule; Flow; Angle of Repose; Discharge Rate; Shear; Rolling friction; Compression; Elastic deformation; Microstructure; Degree of compression; Tensile strength; Galenisk farmaci; Pharmaceutics;

    Abstract : Simulations are powerful and important tools for gaining insight into powder processes. Ultimately, simulations have the potential to replace experiments. Thus, accurate models and insight into the essential factors for descriptions of powder behaviour are required. READ MORE

  7. 5. Preparation of Pharmaceutical Powders using Supercritical Fluid Technology : Pharmaceutical Applications and Physicochemical Characterisation of Powders

    Author : Sitaram Velaga; Johan Carlfors; Kristiina Järvinen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; Supercritical fluid; Gas Anti-Solvent; SEDS; Crystallisation; Particle design; Polymorphs; Dry powder inhalation; Solid-state behaviour; Therapeutic proteins; Precipitation; Stability; Recombinant human growth hormone hGH ; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Abstract : The main aim of the thesis was to explore the potential of supercritical fluid (SF) techniques in the field of drug delivery. In particular, the relatively recently developed solution-enhanced dispersion by supercritical fluids (SEDS) technology has been employed in the preparation of particles/powders. READ MORE