Search for dissertations about: "pharmacodynamic"

Showing result 1 - 5 of 107 swedish dissertations containing the word pharmacodynamic.

  1. 1. Models for Ordered Categorical Pharmacodynamic Data

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Per-Henrik Zingmark; Mats O Karlsson; E. Niclas Jonsson; France Mentré; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Pharmacodynamic; Modelling; Categorical data; NONMEM; Proportional odds model; Markov model; Differential drug effect model; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI;

    Abstract : In drug development clinical trials are designed to investigate whether a new treatment is safe and has the desired effect on the disease in the target patient population. Categorical endpoints, for example different ranking scales or grading of adverse events, are commonly used to measure effects in the trials. READ MORE

  2. 2. Characterization of the antinociceptive effects of morphine and its glucuronides : Pharmacokinetic-pharmacodynamic modeling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marie Gårdmark; [1998]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

    Abstract : Pharmacodynamic modeling was used to quantify the time aspects of theantinociceptive effect in rats following administration of morphine, morphine-3-glucuronide (M3G) and morphine-glucuronide (M6G). M6G acts as a potentagonist of morphine actions, whereas the pharmacodynamic role of M3G has beenunclear. READ MORE

  3. 3. Pharmacodynamic effects of antibiotics : studies on bacterial morphology, initial killing, postantibiotic effect and effecitive regrowth time

    University dissertation from Linköping : Linköpings universitet

    Author : Håkan Hanberger; Otto Cars; [1992]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : Pharmacodynamics of antibiotics deals with time course of drug activity and mechanisms of action of drugs on bacteria. In this thesis pharmacodynamic parameters have been studied after brief exposure of gram-positive bacteria to daptomycin, imipenem or vancomycin and after short exposure of gram-negative bacteria to amikacin, ampicillin, aztreonam, cefepime, cefotaxime, ceftazidime, ceftriaxone, cefuroxime, imipenem, mecillinal,11, or piperacillin. READ MORE

  4. 4. Midazolam in total intravenous anaesthesia : pharmacodynamic and pharmacokinetic aspects

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anders Nilsson; [1987]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  5. 5. Direct Thrombin Inhibitors in Treatment and Prevention of Venous Thromboembolism: Dose – Concentration – Response Relationships

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Marie Cullberg; Mats O. Karlsson; Ulf G. Eriksson; Nick H.G. Holford; [2006]
    Keywords : Pharmaceutical biosciences; Ximelagatran; pharmacokinetic; pharmacodynamic; activated partial thromboplastin time; utility function; dosing strategy; venous thromboembolism; NONMEM; Farmaceutisk biovetenskap;

    Abstract : For prevention and treatment of thrombotic diseases with an anticoagulant drug it is important that an adequate dose is given to avoid occurrence or recurrence of thrombosis, without increasing the risk of bleeding and other adverse events to unacceptable levels. The aim of this thesis was to develop mathematical models that describe the dose-concentration (pharmacokinetic) and concentration-response (pharmacodynamic) relationships of direct thrombin inhibitors, in order to estimate optimal dosages for treatment and long-term secondary prevention of venous thromboembolism (VTE). READ MORE