Search for dissertations about: "pharmacodynamic"
Showing result 11 - 15 of 123 swedish dissertations containing the word pharmacodynamic.
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11. Pharmacokinetic and pharmacodynamic analysis of antidiuretic peptides
Abstract : The clinical pharmacology of desmopressin and a new vasopressin analogue (F992) was investigated in healthy human subjects. The common procedure of overhydration of healthy volunteers when studying the antidiuretic effect of a drug, may affect the pharmacokinetics, in particular the volumes of distribution. READ MORE
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12. Pharmacokinetic-Pharmacodynamic modeling and prediction of antibiotic effects
Abstract : Problems of emerging antibiotic resistance are becoming a serious threat worldwide, and at the same time, the interest to develop new antimicrobials has declined. There is consequently a need for efficient methods to develop new treatments that minimize the risk of resistance development and that are effective on infections caused by resistant strains. READ MORE
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13. Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel
Abstract : Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. READ MORE
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14. Clonidine in paediatric anaesthesia : pharmacokinetic and pharmacodynamic aspects
Abstract : Clonidine is a mixed alpha-2/alpha-1 adrenoceptor agonist. It reduces sympathetic and increases parasympathetic tone which results in a lowering of the baseline blood pressure and heart rate. READ MORE
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15. Pharmacokinetics of haloperidol and clozapine with pharmacodynamic considerations
Abstract : .... READ MORE