Search for dissertations about: "pharmacodynamics"

Showing result 1 - 5 of 98 swedish dissertations containing the word pharmacodynamics.

  1. 1. Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites

    Author : Marie V Magnusson; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; Pentoxifylline; metabolites; pharmacodynamics;

    Abstract : Pentoxifylline is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). READ MORE

  2. 2. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy

    Author : Sofia Friberg Hietala; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : pharmacokinetics; pharmacodynamics; antimalarials; artemisinins;

    Abstract : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. READ MORE

  3. 3. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination

    Author : Mats O. Magnusson; Rikard Sandström; Mats Karlsson; Ulf Bredberg; Uppsala universitet; []
    Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Enzyme induction; Time course; Turnover model; Mechanism-based; Modelling; NONMEM; Farmakokinetik Farmakoterapi;

    Abstract : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. READ MORE

  4. 4. Premedication for intubation in newborn infants; pain assessment, pharmacokinetics and pharmacodynamics

    Author : Elisabeth Norman; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Premedication; pain; premature; newborn; aEEG; randomized controlled trial; thiopental; morphine; remifentanil; rapid sequence induction; ibntubation; pharmacokinetics; pharmacodynamics;

    Abstract : Preterm infants undergo intensive care during a vulnerable period with hemodynamic instability and a rapidly developing and immature CNS. Adequate pain management is essential, since pain experience might lead to acute physiological reactions as well as neurological and neuropsychological sequels. READ MORE

  5. 5. In vitro Pharmacodynamics of Antifungal Agents in the Treatment of Candida Infections

    Author : Anders Lignell; Jan Sjölin; Elisabeth Löwdin; Mats Kalin; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amphotericin B; antagonism; Candida; human serum; inhibition; interaction; in vitro; kinetic model; pharmacodynamics; pharmacokinetics; posaconazole; protein binding; voriconazole; Infectious diseases; Infektionssjukdomar; Infektionssjukdomar; Infectious Diseases;

    Abstract : Pharmacodynamic studies are important for the optimal use of antimicrobial agents. Combination antifungal therapy may be one method to improve outcome in invasive Candida infections. READ MORE