Search for dissertations about: "pharmacodynamics"
Showing result 6 - 10 of 111 swedish dissertations containing the word pharmacodynamics.
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6. In vitro Pharmacodynamics of Antifungal Agents in the Treatment of Candida Infections
Abstract : Pharmacodynamic studies are important for the optimal use of antimicrobial agents. Combination antifungal therapy may be one method to improve outcome in invasive Candida infections. READ MORE
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7. Mechanistic Based Pharmacokinetic-Pharmacodynamics models for Drug Interactions and Disease Population Predictions
Abstract : Therapeutic dose of a medication refers to the quantity of a drug required to produce a pharmacological effect without causing unacceptable adverse events. Dose selection in the clinical setting is not straight forward due to various factors, including specific patient factors such as age, sex, weight, genetic variants and renal/hepatic function, as well as external factors such as food and co-medication, all of which can influence the efficacy and safety of a drug. READ MORE
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8. New Approaches for Levodopa Treatment in Parkinson’s Disease
Abstract : Parkinson’s disease (PD) is characterized by degeneration of dopaminergic cells, which results in dopamine depletion. Levodopa is the most effective symptomatic treatment, however, disease progression along with the unfavorable pharmacokinetics of levodopa makes the disease increasingly difficult to treat with time. READ MORE
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9. Pharmacokinetic and pharmacodynamic analysis of antidiuretic peptides
Abstract : The clinical pharmacology of desmopressin and a new vasopressin analogue (F992) was investigated in healthy human subjects. The common procedure of overhydration of healthy volunteers when studying the antidiuretic effect of a drug, may affect the pharmacokinetics, in particular the volumes of distribution. READ MORE
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10. Pharmacokinetic-Pharmacodynamic modeling and prediction of antibiotic effects
Abstract : Problems of emerging antibiotic resistance are becoming a serious threat worldwide, and at the same time, the interest to develop new antimicrobials has declined. There is consequently a need for efficient methods to develop new treatments that minimize the risk of resistance development and that are effective on infections caused by resistant strains. READ MORE