Search for dissertations about: "pharmacokinetic in vitro"

Showing result 1 - 5 of 79 swedish dissertations containing the words pharmacokinetic in vitro.

  2. 1. Artemisinin and its derivatives in the treatment of falciparum malaria : in vitro/in vivo efficacy and pharmacokinetic investigations

    Author : Mohamed Hassan Alin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Abstract : .... READ MORE

  4. 2. First-pass Intestinal Metabolism of Drugs : Experiences from in vitro, in vivo and simulation studies

    Author : Helena Anna Thörn; Hans Lennernäs; Paul Alfred Dickinson; Brian Houston; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; metabolism; CYP3A4; CYP2C9; CYP2D6; UGT; glucuronidation; physiologically based pharmacokinetic model; modelling; Biopharmaceutics; Biofarmaci;

    Abstract : The bioavailability of a drug can be described as the fraction of an orally administered dose that reaches the systemic circulation and is often limited by first-pass metabolism in the gut and the liver. It is important to have knowledge about these processes since the systemic blood drug concentration is tightly connected to the effect of the drug. READ MORE

  5. 3. Drug resistance in acute myeloid leukemia : pharmacokinetic and in vitro studies

    Author : Lars Möllgård; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chemotherapy has improved clinical outcome in adult acute myeloid leukemia (AML) but still the majority of the patients die of their disease. One important explanation is transport mediated drug resistance resulting in refractory or relapsing disease. P-glycoprotein (Pgp) is located in the membrane and can extrude cytostatic drugs. READ MORE

  6. 4. Zopiclone degradation in biological samples : Characteristics and consequences in forensic toxicology

    Author : Gunnel Nilsson; Robert Kronstrand; Fredrik C. Kugelberg; Johan Ahlner; Mikael Hedeland; Linköpings universitet; []
    Keywords : ;

    Abstract : Bio-analytical results are influenced by in vivo factors such as genetics, pharmacological and physiological conditions and in vitro factors such as specimen composition, sample additives and storage conditions. Zopiclone (ZOP) is a short-acting hypnotic drug (Imovane®) used for treatment of insomnia. READ MORE

  7. 5. In vitro and in vivo studies of artemisinin endoperoxides

    Author : Therese Ericsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Artemisinin; Artesunate; Breast cancer; Cytochrome P450; Dihydroartemisinin; Inhibition; LC-MS MS; Pharmacokinetics; Plasma; Saliva;

    Abstract : Artemisinin and its semi-synthetic derivatives (eg. Artemether/ARM, artesunate/ARS, dihydroartemisinin/DHA) play an important role in combating malaria, and treatments containing an artemisinin derivative (artemisinin-based combination therapies, ACTs) are today the standard treatment worldwide for Plasmodium falciparum malaria. READ MORE