Search for dissertations about: "pharmacokinetic models"
Showing result 16 - 20 of 80 swedish dissertations containing the words pharmacokinetic models.
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16. Development and Evaluation of Nonparametric Mixed Effects Models
Abstract : A nonparametric population approach is now accessible to a more comprehensive network of modelers given its recent implementation into the popular NONMEM application, previously limited in scope by standard parametric approaches for the analysis of pharmacokinetic and pharmacodynamic data. The aim of this thesis was to assess the relative merits and downsides of nonparametric models in a nonlinear mixed effects framework in comparison with a set of parametric models developed in NONMEM based on real datasets and when applied to simple experimental settings, and to develop new diagnostic tools adapted to nonparametric models. READ MORE
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17. Pharmacokinetic-Pharmacodynamic modeling and prediction of antibiotic effects
Abstract : Problems of emerging antibiotic resistance are becoming a serious threat worldwide, and at the same time, the interest to develop new antimicrobials has declined. There is consequently a need for efficient methods to develop new treatments that minimize the risk of resistance development and that are effective on infections caused by resistant strains. READ MORE
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18. Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel
Abstract : Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. READ MORE
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19. Covariate Model Building in Nonlinear Mixed Effects Models
Abstract : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. READ MORE
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20. Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies
Abstract : Antibiotics are among the most commonly prescribed drugs. Although the majority of these drugs were developed several decades ago, optimal dosage (dose, dosing interval and treatment duration) have still not been well defined. READ MORE