Search for dissertations about: "pharmacokinetics"

Showing result 1 - 5 of 263 swedish dissertations containing the word pharmacokinetics.

  1. 1. Piperaquine - Bioanalys, drug metabolism and pharmacokinetics

    University dissertation from Göteborg : Göteborg University

    Author : Joel Tärning; Göteborgs universitet.; Gothenburg University.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Piperaquine; malaria; Plasmodium falciparum; antimalarials; ACT; pharmacokinetics; NONMEM; population pharmacokinetics; NCA; bioavailability; enterohepatic circulation; metabolism; metabolites; animal models; bioanalysis; regression models; validation; HPLC; LC-MS MS; H-NMR; FTICR-MS;

    Abstract : Malaria is one of the most abundant parasitic diseases in the world affecting many of the poorest economies. The estimated prevalence is 300 to 700 million clinical episodes each year with up to 3 million deaths. READ MORE

  2. 2. Pharmacokinetics and Pharmacodynamics of Oxycodone and Morphine with Emphasis on Blood-Brain Barrier Transport

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Emma Boström; Uppsala universitet.; [2007]
    Keywords : Pharmacokinetics Pharmacotherapy; pharmacokinetics; pharamcodynamics; blood-brain barrier; oxycodone; microdialysis; NONMEM; brain distribution; transport; Farmakokinetik Farmakoterapi;

    Abstract : The pharmacokinetics and pharmacodynamics of oxycodone and morphine was investigated and related to the transport across the blood-brain barrier (BBB) in rats. The influence of a P-glycoprotein (P-gp) inhibitor on the plasma pharmacokinetics and pharmacodynamics of oxycodone was evaluated. READ MORE

  3. 3. Piperaquine and Metabolites - Bioanalysis and Pharmacokinetics

    University dissertation from Göteborg : Göteborgs universitet

    Author : Mohd Yusmaidie Aziz; Göteborgs universitet.; Gothenburg University.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioanalysis; Pharmacokinetics; Piperaquine; Malaria;

    Abstract : Antimalarial piperaquine (PQ) is currently used as a partner drug with dihydroartemisinin (DHA), exhibiting high cure rates (>95%) for P. falciparum. Despite its raising usage worldwide with DHA, PQ is synthetically developed outside of big pharma pipelines. READ MORE

  4. 4. Pharmacokinetics and pharmacodynamics of pentoxifylline and metabolites

    University dissertation from Lund University, Faculty of Medicine

    Author : Marie V Magnusson; Lunds universitet.; Lund University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; Pentoxifylline; metabolites; pharmacodynamics;

    Abstract : Pentoxifylline is a haemorheologic drug with complex pharmacokinetics and pharmacodynamics due to both reversible metabolism and the formation of active metabolites. In humans, pentoxifylline is metabolised to at least seven phase 1 metabolites (M1-M7). READ MORE

  5. 5. Clinical pharmacokinetics and pharmacodynamics of antimalarial combination therapy

    University dissertation from Lund University, Faculty of Medicine

    Author : Sofia Friberg Hietala; Göteborgs universitet.; Gothenburg University.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; antimalarials; artemisinins;

    Abstract : In the face of growing drug resistance, the World Health Organization (WHO) has issued recommendations strongly encouraging the use of combination therapies to combat uncomplicated malaria. Amongst the most effective treatments are those combining an artemisinin derivative with a longer acting component such as amodiaquine, lumefantrine or piperaquine. READ MORE