Search for dissertations about: "pharmacokinetics"
Showing result 31 - 35 of 303 swedish dissertations containing the word pharmacokinetics.
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31. Optimization of first-line anti-tuberculosis therapy in patients co-infected with HIV
Abstract : Every year over one million people die from tuberculosis. People infected with HIV are significantly more vulnerable to tuberculosis, which is the leading cause of HIV-associated death. The first-line treatment for tuberculosis consists of rifampicin, isoniazid, pyrazinamide and ethambutol. READ MORE
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32. In vivo Pharmacokinetic Interactions of Finasteride and Identification of Novel Metabolites
Abstract : The general aim of this thesis was to improve the understanding of the in vivo pharmacokinetics and, in particular, the metabolism of finasteride, a 5α-reductase inhibitor used in the treatment of enlarged prostate glands and male pattern baldness. CYP3A4 has been identified as the major enzyme involved in the sequential metabolism of finasteride to ω-OH finasteride (M1) and ω-COOH finasteride (M3). READ MORE
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33. Renal dysfunction in orthopaedic surgery - with special reference to drug effects in the elderly
Abstract : Total hip replacement (THR) is a common procedure, generally performed in elderly persons. Previous studies indicated that the use of isoxazolyl penicillins could induce a transient post-operative renal dysfunction in these patients. READ MORE
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34. New Approaches for Levodopa Treatment in Parkinson’s Disease
Abstract : Parkinson’s disease (PD) is characterized by degeneration of dopaminergic cells, which results in dopamine depletion. Levodopa is the most effective symptomatic treatment, however, disease progression along with the unfavorable pharmacokinetics of levodopa makes the disease increasingly difficult to treat with time. READ MORE
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35. Pharmacokinetic and pharmacodynamic analysis of antidiuretic peptides
Abstract : The clinical pharmacology of desmopressin and a new vasopressin analogue (F992) was investigated in healthy human subjects. The common procedure of overhydration of healthy volunteers when studying the antidiuretic effect of a drug, may affect the pharmacokinetics, in particular the volumes of distribution. READ MORE