Search for dissertations about: "pharmacokinetics"

Showing result 6 - 10 of 268 swedish dissertations containing the word pharmacokinetics.

  1. 6. Pharmacokinetics and dosimetry in intraperitoneal radioimmunotherapy with 211At

    University dissertation from Göteborg : University of Gothenburg

    Author : Elin Cederkrantz; Göteborgs universitet.; Gothenburg University.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; astatine-211; radioimmunotherapy; alpha-emitter; ovarian cancer; MX35; pharmacokinetics; dosimetry; effective dose;

    Abstract : The prognosis for patients diagnosed with disseminated cancer is often poor. Radioimmunotherapy (RIT) is a new approach to treat disseminated disease. The aim is to target tumor cells with monoclonal antibodies (mAbs) labeled with radionuclides which release cytotoxic particle radiation upon decay. The radionuclide 211At, with half-life 7. READ MORE

  2. 7. Pharmacogenetic Studies of Paclitaxel in Ovarian Cancer focus on interindividual differences in pharmacodynamics and pharmacokinetics

    University dissertation from Institutionen för medicin och vård

    Author : Henrik Green; Linköpings universitet.; Linköpings universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacogenetics; paclitaxel; LC MS; Taxol; ovarian cancer; pharmacokinetics; CYP2C8; CYP3A4; ABCB1; äggstockscancer; paklitaxel; MEDICINE Physiology and pharmacology Pharmacological research Clinical pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Klinisk farmakologi;

    Abstract : Ovarian cancer is one of the most common female cancer diseases in the world today and in Sweden more than 800 new cases are diagnosed every year. The standard treatment consists of chemotherapy with paclitaxel in combination with carboplatin after initial cytoreductive surgery. READ MORE

  3. 8. Pharmacokinetics and dosimetry of radiolabelled octreotide for tumour therapy

    University dissertation from Göteborg

    Author : Peter Bernhardt; Göteborgs universitet.; Gothenburg University.; [2000]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; radiation dosimetry; therapy; radionuclides; octreotide; neuroendocrine tumours; nude mice; patients;

    Abstract : Somatostatin (SS) receptors (sstr) are usually highly expressed on neuroendocrine (NE) tumours. The radiolabelled SS analogue 111In-DTPA-D-Phe1-octreotide is today widely used to scintigraphically visualise NE tumours, and high 111In activity concentrations are obtained in tumour vs. normal tissues. READ MORE

  4. 9. Pharmacodynamics of Enzyme Induction and its Consequences for Substrate Elimination

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mats O. Magnusson; Uppsala universitet.; [2007]
    Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Enzyme induction; Time course; Turnover model; Mechanism-based; Modelling; NONMEM; Farmakokinetik Farmakoterapi;

    Abstract : Enzyme induction is a process whereby a molecule enhances the expression of enzymes. If the affected enzymes are involved in the elimination of a drug, this may result in a drug interaction. Induction is therefore of major concern during drug development and in clinical practice. READ MORE

  5. 10. Pharmacokinetic drug-drug interactions in the management of malaria, HIV and tuberculosis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Doaa Elsherbiny; Uppsala universitet.; [2008]
    Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Drug-drug interactions; Cytochrome P-450; Artemisinin antimalarials; Nevirapine; Lopinavir; Rifampicin; NONMEM; Farmakokinetik Farmakoterapi;

    Abstract : Malaria, Human Immunodeficiency Virus (HIV) and tuberculosis (TB) are global health problems having their worst situation in sub-Saharan Africa. Consequently, concomitant use of antimalarial, antiretroviral and antitubercular drugs may be needed, resulting in a potential risk of drug-drug interactions. READ MORE