Search for dissertations about: "pharmacology CNS"

Showing result 1 - 5 of 24 swedish dissertations containing the words pharmacology CNS.

  2. 1. Transcription Factor AP-2 in Relation to Serotonergic Functions in the Central Nervous System

    Author : Mattias Damberg; Elias Eriksson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; CNS; serotonin; transcription factors; AP-2; personality; antidepressants; Farmakologi; Pharmacological research; Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Abstract : Eukaryotic gene transcription plays a regulatory role in mammalian developmental processes. It has been shown that transcriptional control is an important mechanism for specification of neurotransmitter phenotypes. READ MORE

  4. 2. Transcription Factor AP-2 in Relation to Personality and Antidepressant Drugs

    Author : Cecilia Berggård; Lars Oreland; Göran Engberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Transcription factors; serotonin; AP-2; antidepressants; CNS; personality; Farmakologi; Pharmacological research; Farmakologisk forskning;

    Abstract : The CNS monoaminergic systems are considered as the head engine regulating neuropsychiatric functions and personality. Transcription factor AP-2 is known to be essential for the development of the brainstem including the monoaminergic nuclei, and has the ability to regulate many genes in the monoaminergic systems. READ MORE

  5. 3. Function, Pharmacology, Evolution and Anatomical Localization of G Protein-Coupled Receptors and Solute Carriers

    Author : Tatjana Haitina; Robert Fredriksson; Gert Flik; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Farmakologi; Medicine; medicin;

    Abstract : The G protein-coupled receptors (GPCRs) and solute carriers (SLC) are two large families of membrane-bound proteins. The aim of this study was to characterize these two families in terms of evolution and function. READ MORE

  6. 4. CNS Targets for GH and IGF-1 : Emphasis on Their Regulation in Relation to Cognitive Processes

    Author : Madeleine Le Grevès; Fred Nyberg; Anders Hallberg; Sigbritt Werner; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; Central nervous system; Growth hormone; Insulin-like growth factor-1; Receptor mRNA regulation; N-methyl-D-aspartate receptor mRNA; Morris water maze; Farmaceutisk farmakologi; Pharmaceutical pharmacology; Farmaceutisk farmakologi;

    Abstract : The interest for the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and its role in the central nervous system (CNS) has grown during the past decade. GH has been associated with psychological functions as sleep, mood, general well-being and learning and memory. READ MORE

  7. 5. Neurotoxicity of β-lactam antibiotics : experimental kinetic and neurophysiological studies

    Author : Silvia E. Schliamser; Ragnar Norrby; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; benzylpenicillin; blood-brain barrier; ß-lactam antibiotics; CSF; CNS; EEG; imipenem cilastatin; FCE 22101; meningitis; neurotoxicity of; silent-second; thiopental; transport system; uraemia;

    Abstract : The neurotoxic potential of intravenous administered benzylpenicillin (BPC) was studied in rabbits with intact blood-CNS barriers and rabbits with experimental E. coli meningitis. At onset of epileptogenic EEG activity or seizures, serum, CSF and brain tissue were collected for assay of BPC. READ MORE