Search for dissertations about: "pharmacometrics"
Showing result 11 - 15 of 46 swedish dissertations containing the word pharmacometrics.
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11. Development and Evaluation of Nonparametric Mixed Effects Models
Abstract : A nonparametric population approach is now accessible to a more comprehensive network of modelers given its recent implementation into the popular NONMEM application, previously limited in scope by standard parametric approaches for the analysis of pharmacokinetic and pharmacodynamic data. The aim of this thesis was to assess the relative merits and downsides of nonparametric models in a nonlinear mixed effects framework in comparison with a set of parametric models developed in NONMEM based on real datasets and when applied to simple experimental settings, and to develop new diagnostic tools adapted to nonparametric models. READ MORE
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12. Application of Mixed-Effect Modeling to Improve Mechanistic Understanding and Predictability of Oral Absorption
Abstract : Several sophisticated techniques to study in vivo GI transit and regional absorption of pharmaceuticals are available and increasingly used. Examples of such methods are Magnetic Marker Monitoring (MMM) and local drug administration with remotely operated capsules. READ MORE
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13. Pharmacometric Models in Anesthesia and Analgesia
Abstract : Modeling is a valuable tool in drug development, to support decision making, improving study design, and aid in regulatory approval and labeling. This thesis describes the development of pharmacometric models for drugs used in anesthesia and analgesia. READ MORE
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14. Pharmacometric models in the development of biological medicinal products
Abstract : Biological medicinal products (BMPs) are a successful class of drugs that are indicated in numerous diseases. Common among them is that complexities associated with their manufacture and analysis lead to a high cost compared to small-molecular weight drugs. READ MORE
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15. Pharmacokinetic-Pharmacodynamic Evaluations and Experimental Design Recommendations for Preclinical Studies of Anti-tuberculosis Drugs
Abstract : Tuberculosis is an ancient infectious disease and a leading cause of death globally. Preclinical research is important for defining drugs and regimens which should be carried forward to human studies. READ MORE