Search for dissertations about: "pharmacy thesis experimental"
Showing result 1 - 5 of 91 swedish dissertations containing the words pharmacy thesis experimental.
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1. Experimental and theoretical predictions of intestinal drug absorption
Abstract : The subject of this thesis is the development of better experimental and computational predictions of the intestinal absorption properties of new drug candidates. In the last decade the drug discovery process has produced an increasing number of new drug candidates by the use of high throughput screening techniques. READ MORE
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2. Modelling and prediction of drug transport processes with experimental and calculated molecular properties : A multivariate approach
Abstract : Less than 2% of the lead compounds generated by the pharmaceutical industry enter the exploratory drug-development phase, from which point they stand only a 10% chance of becoming a commercial medicine. A large proportion of the compounds fail due to poor biopharmaceutical properties, such as permeability and solubility. READ MORE
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3. Communication and teamwork : Studies of the impact on quality of drug use in swedish nursing homes
Abstract : This thesis examines factors that affect the quality of drug-use practices in Swedish nursing homes.The analysis comprises six consecutive studies. READ MORE
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4. Computational models for the prediction of intestinal membrane permeability
Abstract : Lead compounds generated in high-throughput drug discovery programs often have unfavorable biopharmaceutical properties, resulting in a low success rate for such drug candidates in clinical development. Efficient and reliable methods that predict biopharmaceutical properties, such as intestinal permeability and solubility are therefore required in order to reduce the attrition rate during development of these compounds. READ MORE
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5. Pharmacodynamic modeling of cardiovascular effects of Σb-antagonists and moxonidine : Special emphasis on tolerance and rebound effects
Abstract : Pharmacodynamic (PD) modeling was used to characterize and quantify the short- and long-term changes in cardiovascular effects following treatment with β-antagonists or imidazoline receptor agonist moxonidine, in spontaneous hypertensive rats and patients with congestive heart failure, respectively. The complex cardiovascular system is regulated by several feedback mechanisms with different time domains and gains. READ MORE
