Search for dissertations about: "pharmacy thesis"
Showing result 11 - 15 of 885 swedish dissertations containing the words pharmacy thesis.
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11. Compression mechanics of pharmaceutical aggregates : Studies on the tabletting of spheronised aggregates with varying composition and porosity
Abstract : The thesis investigated the tabletting behaviour of aggregates of different porosity and material composition, and focused on the role of the compression mechanics of the aggregates as a link between their structure and composition and the structure and functionality of tabletsformed from them. The aggregates studied all responded to compression by deformation and densification. READ MORE
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12. Modelling and prediction of drug transport processes with experimental and calculated molecular properties : A multivariate approach
Abstract : Less than 2% of the lead compounds generated by the pharmaceutical industry enter the exploratory drug-development phase, from which point they stand only a 10% chance of becoming a commercial medicine. A large proportion of the compounds fail due to poor biopharmaceutical properties, such as permeability and solubility. READ MORE
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13. Tabletting behaviour of aggregates : Mechanistical conception and modulation by variations in aggregate physical properties
Abstract : The volume reduction mechanisms involved during compression of aggregates prepared from microcrystalline cellulose particles and effects of variations in their physical properties on their compression behaviour and compactability were studied in this thesis.The dominating volume reduction mechanisms during compression of aggregates prepared of MCC were deformation (bulk deformation and local deformation) parallel with densification, and generally the degree of fragmentation of the aggregates was minute. READ MORE
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14. Pulmonary Drug Absorption : In vitro and in vivo investigations of drug absorption across the lung barrier and its relation to drug physicochemical properties
Abstract : Although, pulmonary drug delivery is a well established means for targeting of drugs to the lungs for the treatment of respiratory diseases as well as for the systemic delivery of volatile anesthetic agents, drug absorption kinetics in the lung have not been subjected to extensive research. The main objective of this thesis was to investigate drug absorption characteristics of the lung barrier, using the isolated and perfused rat lung model and in vivo pharmacokinetic studies in rats. READ MORE
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15. Characterization of the antinociceptive effects of morphine and its glucuronides : Pharmacokinetic-pharmacodynamic modeling
Abstract : Pharmacodynamic modeling was used to quantify the time aspects of theantinociceptive effect in rats following administration of morphine, morphine-3-glucuronide (M3G) and morphine-glucuronide (M6G). M6G acts as a potentagonist of morphine actions, whereas the pharmacodynamic role of M3G has beenunclear. READ MORE
