Search for dissertations about: "phenotypic integration"
Showing result 1 - 5 of 14 swedish dissertations containing the words phenotypic integration.
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1. Behaviour under predation risk - antipredator strategies, behavioural syndromes and sex-specific responses in aquatic prey
Abstract : In many natural ecosystems, predation is well recognized as a strong evolutionary force, and predator-mediated selection has been demonstrated to induce changes in prey morphology, life history and behaviour. In my thesis, I have focused on behavioural responses in aquatic prey under the risk of predation. READ MORE
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2. In vivo properties of neural stem cells after transplantation into the rat brain-Studies of phenotypic differentiation and functional integration using cell-specific labelling and electrophysiological techniques
Abstract : In the present thesis, we have examined the in vivo properties of in vitro expanded human and rat neural stem-and progenitor cells after transplantation into the neonatal and adult rat brain. The survival and differentiation of the grafted cells were assessed using species-specific antisera, and pre-labelling with the reporter gene green fluorescent protein (GFP). READ MORE
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3. Cell Replacement Therapy for Parkinson's Disease: Potential for Circuitry Repair
Abstract : The derivation of dopamine neurons from human embryonic stem cells (hESCs) now offers a promising alternative to fetal tissue for cell replacement therapy (CRT) in Parkinson´s disease (PD). Using the appropriate chemical cues in vitro, hESCs can be patterned towards bona-fide ventral midbrain (VM) DA neurons that survive, reinnervate, release DA and provide functional recovery when transplanted into rodent and non-human primate models of PD. READ MORE
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4. Statistical methods for the detection, analyses and integration of biomarkers in the human genome and transcriptome
Abstract : Most human diseases have been shown to have a genetic basis that is linked to regulation of gene expression at the transcriptional or post-transcriptional level. In the central dogma of biology, deoxyribonucleic acid (DNA) is transcribed to messenger ribonucleic acid (mRNA), and then translated into proteins; dysfunction in any of these processes may contribute to the development of disease. READ MORE
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5. A phenotypic study of a unique respiratory strain of Saccharomyces cerevisiae and its application in protein production
Abstract : During aerobic growth at high glucose concentrations, the yeast Saccharomyces cerevisiae prefers to catabolise glucose through fermentation rather than through respiration. Previously fully respiratory growth could only be achieved when a low external glucose concentration was maintained, in fed-batch and continuous cultures, but since the development of the respiratory strain, TM6*, in our laboratory this can now be achieved even at high external glucose concentration. READ MORE