Search for dissertations about: "phenotypic modulation"

Showing result 16 - 20 of 30 swedish dissertations containing the words phenotypic modulation.

  2. 16. Studies on the functional interaction of translation initiation factor IF1 with ribosomal RNA

    Author : Jaroslav Belotserkovsky; Leif Isaksson; Diarmaid Hughes; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; ribosome; rRNA mutation; molekylärgenetik; Molecular Genetics;

    Abstract : Translation initiation factor IF1 is a small, essential and ubiquitous protein factor encoded by a single infA gene in bacteria. Although several important functions have been attributed to IF1, the precise reason for its indispensability is yet to be defined. READ MORE

  4. 17. Studies on extracellular matrix proteins in vascular disease

    Author : Åsa Ström; Kärlväggsbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; smooth muscle cells; osteopontin; extracellular matrix; atherosclerosis;

    Abstract : The composition of the vascular extracellular matrix (ECM) is altered during remodeling conditions such as atherosclerosis. The changed ECM regulates events that are important for the progression of disease including smooth muscle cell (SMC) behaviour and collagen fiber formation. READ MORE

  5. 18. Role of GPS2 in epigenome alterations linked to metaflammation

    Author : Zhiqiang Huang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Current evidence suggests that transcriptional and epigenomic reprogramming events, triggered by transcription factors and chromatin-modifying co-regulators, are of central importance for disease development. G-protein pathway suppressor 2 (GPS2) is a key component of the HDAC3 co-repressor complex that has been earlier implicated in cholesterol homeostasis and anti-inflammatory crosstalk. READ MORE

  6. 19. Human natural killer cell activation and differentiation in health and viral infection

    Author : Niklas Björkström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells are lymphocytes that belong to the innate immune system. They are important for the early defense against viral infections and provide tumor Immune surveillance against both solid tumors and leukemias as well as in settings of hematopoietic stem cell transplantation. READ MORE

  7. 20. Regulation of Autoimmunity and Inflammation by microRNAs and Environmental Factors

    Author : Neivis Tormo-Badia; Diabetes - immunovirologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Tolerance is crucial for maintaining immunological balance and avoid autoimmune diseases like type 1 diabetes and the inflammatory bowel disease, ulcerative colitis (UC). In Study I, we have investigated the regulatory role of a class of noncoding RNAs, the miRNAs, during thymocyte development of the where central tolerance is established. READ MORE