Search for dissertations about: "phlorizin"

Found 3 swedish dissertations containing the word phlorizin.

  2. 1. Effect of hyperglycemia on glucose transport and intracellular signal transduction in skeletal muscle

    Author : Yuichi Kawano; Karolinska Institutet; Karolinska Institutet; []
    Keywords : skeletal muscle; glucose transport; insulin signaling; hyperglycemia; PKC; Akt kinase; GotoKakizaki rat; phlorizin; muscle fiber type;

    Abstract : Recent studies revealing the components of insulin signal transduction have raised the question of whether the defects in insulin signaling account for disturbed glucose metabolism in people with NIDDM. The major focus of this thesis is to elucidate the role of insulin signal transduction in the development of peripheral insulin resistance. READ MORE

  4. 2. Insulin signal transduction in skeletal muscle : special consideration for insulin resistance and diabetes

    Author : Xiao Mei Song; Karolinska Institutet; Karolinska Institutet; []
    Keywords : exercise; fiber-type; glucose transport; hyperglycemia; obesity; signal transduction; skeletal muscle; NIDDM;

    Abstract : This dissertation work is focused on the insulin-signal-transduction pathways to glucose transport in skeletal muscle from animal models of NIDDM. The overall objective is to determine the effectiveness of different pharmacological treatments to improve insulin action in skeletal muscle. READ MORE

  5. 3. Islet glucose metabolism and insulin release in two animal models of glucose intolerance

    Author : Zong-Chao Ling; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Goto-Kakizaki GK rat; transgenic mice; glucose-6-phosphatase activity; insulin secretion; glucocorticoids; [alpha]2-adrenergic receptors; hyperglycemia;

    Abstract : Type 2 diabetes is a complex and heterogenous disease resulting from the interaction of defects of both genetic and environmental origin. Abnormalities contributing to the pathogenesis of type 2 diabetes include impaired [beta]-cell function, peripheral insulin resistance and increased hepatic glucose production. READ MORE