Search for dissertations about: "phorbol ester"

Showing result 1 - 5 of 25 swedish dissertations containing the words phorbol ester.

  2. 1. The Myc network of growth regulators and its interplay with growth and differentiation signals

    Author : Siqin Wu; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Myc; Mad1; p21Cip1; phorbol ester; IFN-g; TGF-b; differentiation; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : The proto-oncogenes/tumor suppressor genes of the Myc/N4ax/Mad network encode transcription factors that are important regulators of cell growth, differentiation, and apoptosis and that are frequently implicated in tumor development. Regulation of their biological functions by growth/differentiation signals as well as their interplay with growth/differentiation signalling pathways play important roles in cell fate determination. READ MORE

  4. 2. Regulation and function of the Mad/Max/Myc network during neuronal and hematopoietic differentiation

    Author : Anne Hultquist; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Myc; Mad1; neuroblastoma; hematopoiesis; phorbol ester; retinoic acid; interferon-g; TGF-b; differentiation.; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : The Mad/Max/Myc transcription factor network takes part in the control of vital cellular functions such as growth, proliferation, differentiation and apoptosis. Dimerization with the protein Max is necessary for the Myc-family of oncoproteins and their antagonists, the Mad-family proteins, to regulate target genes and carry out their intended functions. READ MORE

  5. 3. The role of PKC in neuronal differentiation and in regulation of the actin cytoskeleton during neurite outgrowth

    Author : Ulrika Trollér; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytogenetics; Genetik; cytogenetik; Rho-family; actin cytoskeleton; neurite; differentiation; PKC; regulatory domain; Genetics;

    Abstract : Protein kinase C (PKC) is a family of serine/threonine kinases subgrouped into classical (α, βI, βII, γ), novel (δ, ε, η, θ) and atypical (ζ, ι/λ) isoforms. PKC can be activated by phorbol esters, and prolonged treatment of neuroblastoma cells has been shown to induce neuronal differentiation with neurite outgrowth and increased expression of neuronal genes. READ MORE

  6. 4. Regulation of NF-κB by Calmodulin

    Author : Åsa Antonsson; Thomas Grundström; Ylva Engström; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; NF-κB; calmodulin; transcription; calcium; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : Cells experience numerous external signals which they must respond to. Such signals arriving at the cell surface are transduced via various signal transduction pathways and often ultimately result in regulation of transcription. READ MORE

  7. 5. Functional and structural characterization of integrins and their ligands ICAM-2, vitronectin and fibronectin in leukocytes

    Author : Rosalba Salcedo Amaya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Leukocytes; Adhesion molecules; Integrins; ICAM-2; Vitronectin; Fibronectin.;

    Abstract : Transient adhesion of leukocytes to cells and extracellular matrices is a crucial process in leukocyte physiology. Cell surface adhesion molecules such as integrins and members of the immunoglobulin (Ig) superfamily are involved. READ MORE