Search for dissertations about: "phosphodiester"
Showing result 1 - 5 of 16 swedish dissertations containing the word phosphodiester.
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1. Modulation of inflammation by immunostimulatory DNA
Abstract : The aim of this thesis was to elucidate the roles of different types of DNA in inflammatory responses. We compared the immune responses to nuclease-protected phosphorothioate oligodeoxynucleotides (S-ODNs) and phosphodiester oligodeoxynucleotides (O-ODNs) that either contained or lacked CpG motifs. READ MORE
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2. Synthesis of phosphate-containing oligosaccharides corresponding to capsular antigen structures from Haemophilus influenzae
Abstract : This thesis describes the synthesis of spacer-equipped di- and trimeric oligosaccharide structures corresponding to fragments of the capsular polysaccharides of Haemophilus influenzae types c and f. Both of these polysaccharides are of the teichoic acid type, built up by disaccharide repeating units linked via interglycosidic phosphodiester bonds. READ MORE
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3. Placental Function : An Epidemiological and Magnetic Resonance Study
Abstract : Placental function is central for normal pregnancy and in many of the major pregnancy disorders. We used magnetic resonance imaging techniques to investigate placental function in normal pregnancy, in early and late preeclampsia and in intrauterine growth restriction. READ MORE
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4. Studies on oligodeoxyribonucleotide (DNA) chemistry
Abstract : This communication discusses some of the more common problems encountered in the chemical synthesis of oligodeoxyribonucleotides. Several new protecting groups are introduced, such as the 2-phenylsulphonylethyl and the fluoren-9-methyl, for terminal phosphodiester protection, during the block synthesis of oligodeoxyribonucleotides, following the Catlin-Cramer approach. READ MORE
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5. Radiolabelled Oligonucleotides for Evaluation of in vivo Hybridisation Utilising PET Methodology
Abstract : Antisense oligonucleotides (ODN) may interfere in gene expression on the basis of hybridising to its complementary messenger RNA (mRNA) sequence in the cell thereby preventing the synthesis of the peptide. Therefore, these ODNs may be potential drugs to treat human diseases by “knocking down” the expression of responsible genes or correcting the maturation process of mRNA in the field called antisense therapy. READ MORE