Search for dissertations about: "phosphodiesterase inhibitor"

Showing result 1 - 5 of 15 swedish dissertations containing the words phosphodiesterase inhibitor.

2. 1. Cyclic nucleotide signalling systems in vascular smooth muscle cells and immune system cells with special reference to phosphodiesterases PDE3 and PDE4

   Author : Dag Ekholm; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HTLV-I; multiple sclerosis; proliferation; phosphorylation; T-lymphocytes; vascular smooth muscle; cloning; protein kinase A; cGMP; cAMP; PDE4; Phosphodiesterase; PDE3; cilostamide; rolipram; Histology; cytochemistry; histochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur;

   Abstract : The cyclic nucleotide signalling systems are important in vascular smooth muscle and in the immune system, and are of interest from a pharmacological point of view. Drugs which interfere with the cyclic nucleotide levels have profound effects on heart, blood vessels and airways and have actual or potential use in several important diseases, such as heart failure, hypertension, arteriosclerosis, asthma and autoimmune diseases. READ MORE

4. 2. Genetic aspects of stroke : association and linkage studies in a northern Swedish population

   Author : Per-Gunnar Wiklund; Birgitta Stegmayr; Kjell Asplund; Dan Holmberg; Alun Evans; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Internal medicine; stroke; genetics; polymorphism; association; linkage; risk factors; plasminogen activator inhibitor-1; tissue plasminogen activator; angiotensin converting enzyme; angiotensin II receptor type 1; phosphodiesterase 4D; Invärtesmedicin; Internal medicine; Invärtesmedicin; medicin; Medicine;

   Abstract : Stroke is a common, multifactorial cardiovascular disease. A stroke event is the result of traditional risk factors (i.e. hypertension, diabetes, smoking), environmental exposures and genetic factors in a complex interplay. READ MORE

5. 3. Vascular and metabolic effects of selective PDE-5 inhibition - clinical and experimental studies

   Author : Lovisa Sjögren; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; MAPK; phosphodiesterase-5 inhibition; JNK; endothelial cells; E-selectine; VCAM-1; HUVEC; TNFa; ICAM-1; inflammation;

   Abstract : ABSTRACT Vascular and metabolic effects of selective PDE-5 inhibition Clinical and experimental studies Lovisa Sjögren Department of Molecular and Clinical Medicine, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg Key words: Type 2 diabetes, phosphodiesterase-5 inhibition, inflammation, endothelial cells, HUVEC. TNFα, ICAM-1, VCAM-1, E-Selectin, JNK, MAPK Background: Type 2 diabetes (T2D) patients show impaired glucose metabolism, endothelial dysfunction, chronic low-grade inflammation as well as an increased risk of cardiovascular disease. READ MORE

6. 4. Vardenafil and methylarginines in pulmonary hypertension

   Author : Anna Sandqvist; Gerhard Wikström; Jörn Schneede; Amrita Ahluwalia; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vardenafil; pulmonary hypertension; pharmacokinetics; haemodynamics; right heart catheterization; adenosine; dimethylarginines; phosphodiesterase type 5 inhibitors; endothelin receptor antagonists; klinisk farmakologi; Clinical Pharmacology;

   Abstract : Background: Pulmonary hypertension (PH) is a rare condition characterized by endothelial dysfunction and vascular remodelling, leading to increased pulmonary vascular resistance (PVR) and right ventricular heart failure. Endothelial dysfunction is associated with an imbalance between vasoconstrictor compounds, such as endothelin and thromboxane A2, and vasodilator compounds, such as prostacyclin and nitric oxide (NO). READ MORE

7. 5. Metabolic and endocrine function of human adipose tissue with focus on regional differences

   Author : Vanessa van Harmelen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : acylation stimulating protein; adipocytes; adipose tissue heterogeneity; adrenoceptors; insulin; leptin; lipogenesis; lipolysis; noradrenaline; plasminogen activator inhibitor-1; preadipocytes; tumour necrosis factor-cc;

   Abstract : The major function of human adipose tissue is to store excess ingested energy and to release free fatty acids after hydrolysis of triglycerides (lipolysis), to meet the energy demands of other organs. Adipose tissue also has a secretory function. READ MORE