Search for dissertations about: "phosphodiesterases"

Showing result 1 - 5 of 8 swedish dissertations containing the word phosphodiesterases.

  2. 1. Cyclic nucleotide signalling systems in vascular smooth muscle cells and immune system cells with special reference to phosphodiesterases PDE3 and PDE4

    Author : Dag Ekholm; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HTLV-I; multiple sclerosis; proliferation; phosphorylation; T-lymphocytes; vascular smooth muscle; cloning; protein kinase A; cGMP; cAMP; PDE4; Phosphodiesterase; PDE3; cilostamide; rolipram; Histology; cytochemistry; histochemistry; tissue culture; Histologi; cytokemi; histokemi; vävnadskultur;

    Abstract : The cyclic nucleotide signalling systems are important in vascular smooth muscle and in the immune system, and are of interest from a pharmacological point of view. Drugs which interfere with the cyclic nucleotide levels have profound effects on heart, blood vessels and airways and have actual or potential use in several important diseases, such as heart failure, hypertension, arteriosclerosis, asthma and autoimmune diseases. READ MORE

  4. 2. Applications of microdialysis in studies of the adrenergic regulation of lipolysis in human skeletal muscle and adipose tissue

    Author : Staffan Enoksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Human; in vivo; microdialysis; ethanol technique; lipolysis; blood flow; microcirculation; skeletal muscle; adipose tissue; adrenoceptors; insulin; forskolin; adenylyl cyclase; phosphodiesterases; glycerol; lactate.;

    Abstract : Lipolysis, i.e., hydrolysis of triaeylglycerol to free fatty acids and glycerol, is a central process in lipid metabolism, and the regulation of lipid metabolism is altered in several common disorders, such as diabetes, obesity and atherosclerosis. READ MORE

  5. 3. The Role of Phosphodiesterase 3B in the Regulation of Insulin Secretion

    Author : Linda Härndahl; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; secreting systems; Endocrinology; beta-cell; diabetes; islet; PDE3B; cAMP;

    Abstract : Pancreatic beta-cell dysfunction and insulin resistance are the two hallmarks of type 2 diabetes. An early sign of beta-cell dysfunction is impaired nutrient-induced insulin release. Several insulin secretagogues act by increasing the formation of intracellular cAMP. READ MORE

  6. 4. Pharmacological evaluation of the NO/cGMP signalling system

    Author : Anna Asplund Persson; Karl-Erik Andersson; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Platelet activation and inhibition are tightly balanced processes, regulated by various endogenous molecules. In this regard, the endothelium plays a key role in mediating inhibition of platelets by releasing nitric oxide (NO) and cAMP-elevating prostaglandins. READ MORE

  7. 5. Regulation of bacterial adaptive behavior by the second messenger cyclic-di-GMP and host components

    Author : Soazig Le Guyon; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : To optimize survival and growth, bacteria have evolved adaptive behaviors that respond to relevant environmental signals. A switch from the motile to the sessile lifestyle is probably the most ancient behavioral transition of microorganisms. READ MORE