Search for dissertations about: "phosphoproteome"

Showing result 1 - 5 of 14 swedish dissertations containing the word phosphoproteome.

  2. 1. The Biophysics of Na+,K+-ATPase in neuronal health and disease

    Author : Evgeny E. Akkuratov; Hjalmar Brismar; Anita Aperia; Stefan Wennmalm; Poul Nissen; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Na ; K -ATPase; NMDA receptor; ouabain; phosphoproteome; oligomerization; rapid-onset dystonia-parkinsonism; Biologisk fysik; Biological Physics;

    Abstract : Na+,K+-ATPase is one of the most important proteins in the mammalian cell. It creates sodium and potassium gradients which are fundamental for the membrane potential and sodium-dependent secondary active transport. READ MORE

  4. 2. Phosphoproteomics to tackle brain disorders : Insight into the murine brain phosphoproteome

    Author : Valentina Siino; Institutionen för immunteknologi; []
    Keywords : Phosphoproteomics; mass spectrometry; brain disorders; neurobiology; phosphorylation;

    Abstract : Brain disorders affect the normal functionality of the brain causing inability in controlling certain behaviours. In the last two decades, despite the technological advancement, many biological questions concerning brain mechanisms and neural networks remain still unclear. READ MORE

  5. 3. Characterizing cancer cell signaling at the protein level : from targeted to proteome and phosphoproteome­‐wide analyses

    Author : Elena Panizza; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Proteins are the effectors of cellular functions and the constituting elements of cellular signaling cascades. The ability to analyze the abundances and the dynamics of proteins is central to dissect cellular signaling and its effects on cell physiology. READ MORE

  6. 4. Genes and proteins controlled by cGMP-PKG during retinal degeneration

    Author : Jiaming Zhou; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retinal degeneration; cell death; cGMP-PKG; organotypic explant culture; RNA sequencing; mass spectrometry;

    Abstract : prevalence was reported as 1:3000-4000 worldwide, making it the main reason for blindness in the working population in industrial countries. The mutations of over 70 genes have been related to this genetic disorder, and there is generally no effective treatment, except for gene therapy for the RPE65 mutations. READ MORE

  7. 5. Apoptosis-related mechanisms in the immature brain after hypoxia-ischemia

    Author : Xiaoyang Wang; Göteborgs universitet; []
    Keywords : hypoxia-ischemia; neonatal; caspase; ERK; XIAP; EPO; asialoEPO; brain;

    Abstract : Aims: To characterize the activation of caspases-3 and extracellular signal-regulated kinase (ERK) in the neonatal brain after hypoxia-ischemia (HI) injury and evaluate the neuroprotective effect of X-linked inhibitor of apoptosis (XIAP) protein, erythropoietin (EPO) and the non-erythropoietic derivative asialoEPO. Methods: Seven-day-old rats or 9-day-old mice were subjected to HI. READ MORE