Search for dissertations about: "phosphoramidite"

Showing result 1 - 5 of 7 swedish dissertations containing the word phosphoramidite.

  1. 1. Silaborations of Unsaturated Compounds

    University dissertation from Stockholm : KTH

    Author : Martin Gerdin; KTH.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allylboration; bismetallation; boron; carbocyclization; catalysis; 1; 3-diene; enantioselective; 1; 6-enyne; interelement; N-heterocyclic carbene; nickel; palladium; phosphine; phosphoramidite; platinum; reaction mechanism; silaboration; silicon; silylborane; stereoselective; MEDICINE Chemistry; MEDICIN Kemi;

    Abstract : This thesis deals with the development of transition metal-catalyzed silaborations of 1,3-dienes and 1,6-enynes. The first part of the thesis describes the development of the enantioselective 1,4-silaboration of 1,3-cyclohexadiene. A number of chiral metal-ligand complexes were evaluated. READ MORE

  2. 2. Novel Methods for Synthesis of High Quality Oligonucleotides

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Andrey Semenyuk; Uppsala universitet.; [2006]
    Keywords : Organic chemistry; oligonucleotide; solid-phase synthesis; RNA synthesis; phosphoramidite; abasic sites; depurination; 2 -O-DTM; protecting group; cartridge; conjugate; dithiomethyl linker; base-stable linker; oligonucleotide purification; nucleoside; Organisk kemi;

    Abstract : The first part of the work describes a procedure of oligonucleotide purification using a reversed-phase cartridge. The developed method employs a very efficient yet mild oligonucleotide detritylation on the cartridge support allowing fast purification of oligonucleotides regardless of their 5´-modification. READ MORE

  3. 3. Synthesis of 18F- and 76Br-labelled oligonucleotide and nucleoside derivatives

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Elisabeth Hedberg; Uppsala universitet.; [1998]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi; organisk kemi; Organic Chemistry;

    Abstract : With the aim of developing synthetic routes to oligodeoxynucleotides and analogues labelled with the positron-emitting radionuclides 18F and 76Br (half-lives 1.8 and 16. READ MORE

  4. 4. Self-adaptable catalysts Importance of flexibility and applications in asymmetric catalysis

    University dissertation from Stockholm : KTH

    Author : Ester Fjellander; KTH.; [2010]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; adaptable; flexible; semi-flexible; symmetry; conformational study; mechanistic study; rotation barrier; VT NMR; asymmetric catalysis; ligand design; allylic alkylation; hydrogenation; azepines; dioxaphosphepines; phosphepines; amines; phosphines; phosphoramidites; phosphinites; palladium; rhodium; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Abstract : The topic of this thesis is the design and synthesis of biaryl-based self adaptableligands for asymmetric metal catalysis. The results discussed in papers I-III are covered, together with some unpublished results concerning substrate-adaptable catalysts. A general survey of self-adaptable catalysts is presented first. READ MORE

  5. 5. Conformationally Constrained Nucleosides Design, Synthesis, and Biochemical Evaluation of Modified Antisense Oligonucleotides

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Oommen P. Varghese; Uppsala universitet.; [2007]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; chemically modified oligonucleotides; azetidine; aza-ENA-T; cyanomethylene locked; free energy of activation; diaxial interactions; chair conformation; stable duplex; human serum; snake venom phosphodiesterase; antisense agents; RNase H; Organisk kemi; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi;

    Abstract : This thesis is concerned with synthesis, structure and biochemical analysis of chemically modified oligonucleotides with potential therapeutic applications. The three types of chemical modifications described here are: (a) A North-East locked 1',2'-azetidine nucleoside (b) A North locked 2',4'-cyanomethylene bridged nucleoside and (c) A 2',4'-aza-ENA-T nucleoside. READ MORE