Search for dissertations about: "phosphoramidite"

Showing result 1 - 5 of 9 swedish dissertations containing the word phosphoramidite.

  1. 1. Silaborations of Unsaturated Compounds

    University dissertation from Stockholm : KTH

    Author : Martin Gerdin; KTH.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allylboration; bismetallation; boron; carbocyclization; catalysis; 1; 3-diene; enantioselective; 1; 6-enyne; interelement; N-heterocyclic carbene; nickel; palladium; phosphine; phosphoramidite; platinum; reaction mechanism; silaboration; silicon; silylborane; stereoselective; MEDICINE Chemistry; MEDICIN Kemi;

    Abstract : This thesis deals with the development of transition metal-catalyzed silaborations of 1,3-dienes and 1,6-enynes. The first part of the thesis describes the development of the enantioselective 1,4-silaboration of 1,3-cyclohexadiene. A number of chiral metal-ligand complexes were evaluated. READ MORE

  2. 2. Novel Methods for Synthesis of High Quality Oligonucleotides

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Andrey Semenyuk; Uppsala universitet.; [2006]
    Keywords : Organic chemistry; oligonucleotide; solid-phase synthesis; RNA synthesis; phosphoramidite; abasic sites; depurination; 2 -O-DTM; protecting group; cartridge; conjugate; dithiomethyl linker; base-stable linker; oligonucleotide purification; nucleoside; Organisk kemi;

    Abstract : The first part of the work describes a procedure of oligonucleotide purification using a reversed-phase cartridge. The developed method employs a very efficient yet mild oligonucleotide detritylation on the cartridge support allowing fast purification of oligonucleotides regardless of their 5´-modification. READ MORE

  3. 3. Synthesis and Applications of P-Chirogenic and Axially Chiral P,N-Phosphines as Ligands and Organocatalyst

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Kristian Andersson; [2011]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; phosphoramidite; organocatalysis; aminophosphine; Nicholas reaction; asymmetric synthesis; phosphine; asymmetric hydrogenation; modular synthesis; P-chirogenic;

    Abstract : This thesis deals with the enantioselective synthesis of chiral mixed phosphorous/nitrogen compounds and some of their applications in asymmetric synthesis. For the most part, the compounds are P-chirogenic, with the chirality centered on the phosphorous atom. The last part of the thesis deals with axially chiral phosphoramidites. READ MORE

  4. 4. Synthesis of 18F- and 76Br-labelled oligonucleotide and nucleoside derivatives

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Elisabeth Hedberg; Uppsala universitet.; [1998]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi; organisk kemi; Organic Chemistry;

    Abstract : With the aim of developing synthetic routes to oligodeoxynucleotides and analogues labelled with the positron-emitting radionuclides 18F and 76Br (half-lives 1.8 and 16. READ MORE

  5. 5. METAL CARBONYL MEDIATED REACTIONS - APPLICATIONS IN THE SYNTHESIS OF POTENTIAL GALECTIN INHIBITORS

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Nuria Parera Pera; [2008]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : AbstractThis work reports the development of an asymmetric version of the Nicholas reaction using monodentate phosphoramidites as ligands, which enables asymmetric synthesis from racemic starting material. In addition, we describe the application of metal carbonyl mediated reactions, such as the Pauson-Khand reaction (PKR) and reactions involving cationic iron carbonyl dienyl complexes, for the synthesis of potential galectin inhibitors, implicated in human inflammatory responses and various pathologies. READ MORE