Search for dissertations about: "phosphorylation"

Showing result 11 - 15 of 874 swedish dissertations containing the word phosphorylation.

  2. 11. Cyclic Nucleotide Phosphodiesterase 3B: Regulation in rat adipocytes and 3T3-L1 cells

    Author : Tova Landström; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3T3-L1 TNF-alpha; adipocyte; insulin; p70S6 kinase; mitogen-activated protein kinase; protein kinase B; phosphatidylinositol-3 kinase; phosphodiesterase 3B; cAMP; lipolysis; phosphorylation; signal transduction; Biochemistry; Metabolism; Biokemi; metabolism;

    Abstract : Insulin stimulation of rat adipocytes results in phosphorylation and activation of the cyclic nucleotide phosphodiesterase 3B (PDE3B), a key enzyme in the antilipolytic signalling pathway of this hormone. In this thesis, the site phosphorylated in PDE3B upon stimulation of rat adipocytes with insulin and/or the beta-adrenergic agonist, isoproterenol is identified. READ MORE

  4. 12. Molecular Mechanism of Growth Hormone - Involvement of Janus Kinase 2, Insulin Receptor Substrate-1 and -2 and Phosphatidylinositol 3-Kinase In the Acute Insulin-Like Effects of Growth Hormone In Primary Rat Adipocytes

    Author : Martin Ridderstråle; Diabetes - klinisk obesitasforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin receptor substrate-1; insulin receptor substrate-2 phosphatidylinositol 3-kinase; signal transducer and activator of transcription 5; janus kinase 2; phosphotyrosine; receptor; phosphorylation; Growth hormone; Metabolism; Biochemistry; rat; adipocyte; lipolysis; lipogenesis; Biokemi; metabolism; Pharmacological sciences; pharmacognosy; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Abstract : Originally studying the molecular mechanisms for the insulin-like effects of growth hormone (GH), lipogenesis and antilipolysis, in isolated rat adipocytes we found that the GH receptor (GHR) was tyrosine phosphorylated in response to GH in cells that were responsive to these effects. Then, as Janus kinase 2 (JAK2) was described as a GH-stimulated and GHR-associated tyrosine kinase, we found that JAK2 was tyrosine phosphorylated in response to GH in responsive cells. READ MORE

  5. 13. Plant aquaporins

    Author : Ingela Johansson; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; water deficit; calcium; plasma membrane; Plant biochemistry; channel; phosphorylation; Växtbiokemi;

    Abstract : Aquaporins are integral membrane proteins that specifically transports water. In plants, aquaporins have been identified in the plasma membrane and in the vacuolar membrane. READ MORE

  6. 14. Using peptide-phage display to capture conditional motif-based interactions

    Author : Gustav Sundell; Ylva Ivarsson; Per Jemth; Attila Reményi; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein-protein interaction; PDZ domain; phosphorylation; peptide-phage display; ProP-PD; phospho-peptide; phosphomimetic substitution; Scribble; NMR; DLG1; PTM; affiinity; Biokemi; Biochemistry;

    Abstract : This thesis explores the world of conditional protein-protein interactions using combinatorial peptide-phage display and proteomic peptide-phage display (ProP-PD). Large parts of proteins in the human proteome do not fold in to well-defined structures instead they are intrinsically disordered. READ MORE

  7. 15. Coarse-grained and atomistic modelling of phosphorylated intrinsically disordered proteins

    Author : Ellen Rieloff; Beräkningskemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; intrinsically disordered proteins; phosphorylation; simulations; Monte Carlo; molecular dynamics; coarse-graining; atomistic; statherin; small-angle X-ray scattering; circular dichroism;

    Abstract : Intrinsically disordered proteins (IDPs) are involved in many biological processes such as signalling, regulation and recognition. One of the main questions regarding IDPs is how sequence, structure and function are related. READ MORE