Search for dissertations about: "phototoxicity"

Found 5 swedish dissertations containing the word phototoxicity.

2. 1. Computational studies of photodynamic drugs, phototoxic reactions and drug design

   Author : Klefah Abrahem Klefah Musa; Leif Eriksson; Nino Russo; Örebro universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NSAIDs; fluoroquinolone; photodegradation; phototoxicity; drug design; DFT; TD-DFT; Biophysical chemistry; Biofysikalisk kemi; Chemistry; Kemi;

   Abstract : The most important criterion when designing new drugs or improving old ones in order to prevent side effects or at least diminish them is drug safety. Treatment of all diseases generally needs use of either topical application or systemic medications (transported in the blood) during a certain period of time. READ MORE

4. 2. Illumination in single cell optical microscopy studies - friend and foe

   Author : Kristofer Bodvard; Chalmers tekniska högskola; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; yeast; transcription factors; signalling; fluorescence microscopy; Saccharomyces cerevisiae; light-induced stress; phototoxicity; single cell imaging;

   Abstract : This thesis focuses on how to use light as a biological stress factor in optical microscopy experiments and simultaneously use the illumination to image the spatial and temporal protein dynamics in single yeast cells. The stress responses to environmental changes other than light have been extensively investigated in budding yeast, Saccharomyces cerevisiae, often using techniques based on population averages. READ MORE

5. 3. Modern Computational Physical Chemistry : An Introduction to Biomolecular Radiation Damage and Phototoxicity

   Author : Jorge Llano; Leif A. Eriksson; Ulf Ryde; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; statistical mechanics; biophysical chemistry; interface; surface thermodynamics; bioelectrochemistry; ionizing radiation; radiation therapy; condensed matter; computational chemistry; nucleic acids; radiation damage; electrode potential; electronic transport; photochemistry; strand break; photodynamic action; cytostatic; solvation; solvated electron; absolute potential; chemical potential; Biologi; Biology; Biologi;

   Abstract : The realm of molecular physical chemistry ranges from the structure of matter and the fundamental atomic and molecular interactions to the macroscopic properties and processes arising from the average microscopic behaviour.Herein, the conventional electrodic problem is recast into the simpler molecular problem of finding the electrochemical, real chemical, and chemical potentials of the species involved in redox half-reactions. READ MORE

6. 4. Exploring nanosystems for biomedical applications focusing on photodynamic therapy and drug delivery

   Author : Vladimir Kirejev; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Photodynamic therapy; PDT enhancement; Nitric oxide; NO-based PDT; Targeted drug delivery; Galectin-3; mTHPP; Cyclodextrin; CD-mTHPP conjugate; PpIX AuNP combination; Two-photon microscopy; FLIM; Cell phototoxicity; Ex vivo skin;

   Abstract : The increasing incidences of cancer and related deaths call for the development of new and improved treatment modalities. Photodynamic therapy (PDT) today is an alternative to conventional treatments, but has limitations. This thesis explores different nanosystems with aim to improve PDT focusing on spectroscopic and ex vivo studies. READ MORE

7. 5. Erythropoietic protoporphyria clinical and epidemiological aspects

   Author : Staffan Wahlin; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Erythropoietic protoporphyria; hematopoietic stem cell transplantation; vitamin D; ferrochelatase mutations; liver transplantation; phototoxicity; anemia; iron deficiency;

   Abstract : Erythropoietic protoporphyria, EPP, is an inherited disease in which the main clinical manifestations are painful cutaneous sensitivity to intense light and liver disease which in some requires liver transplantation for survival. This thesis originated in questions and perceived limitations in understanding that accompanied the management of the patient in Study I. READ MORE