Search for dissertations about: "physiologically based pharmacokinetic model"

Showing result 1 - 5 of 10 swedish dissertations containing the words physiologically based pharmacokinetic model.

  1. 1. Physiologically based pharmacokinetic modeling in risk assessment - Development of Bayesian population methods

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Fredrik Jonsson; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; methyl chloride; dichloromethane; toluene; styrene; uncertainty; intra- individual variability; risk assessment; physiologically based modeling; Markov chain Monte Carlo; PBPK; Bayesian; population modeling; Farmaceutisk biovetenskap; PHARMACY Biopharmacy; FARMACI Biofarmaci; Biopharmaceutics; biofarmaci;

    Abstract : In risk assessment of risk chemicals, variability in susceptibility in the population is an important aspect. The health hazard of a pollutant is related to the internal exposure to the chemical, i.e. the target dose, rather than the external exposure. READ MORE

  2. 2. Improved Methods for Pharmacometric Model-Based Decision-Making in Clinical Drug Development

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anne-Gaëlle Dosne; Mats O. Karlsson; Rik Schoemaker; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; confirmatory trials; residual error modeling; parameter uncertainty; sampling importance resampling; model-averaging; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Pharmacometric model-based analysis using nonlinear mixed-effects models (NLMEM) has to date mainly been applied to learning activities in drug development. However, such analyses can also serve as the primary analysis in confirmatory studies, which is expected to bring higher power than traditional analysis methods, among other advantages. READ MORE

  3. 3. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Salim Bouchene; Mats O. Karlsson; Wilhelm Huisinga; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBPK model; endotoxin; colistin; WBPBPK-PD; CMS; inflammation; tissue distribution; Kp; predictions in tissue; interspecies scaling;

    Abstract : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. READ MORE

  4. 4. Physiologically based modelling of nanoparticle biodistribution and biokinetics

    University dissertation from Stockholm : Karolinska Institutet, Institute of Environmental Medicine

    Author : Ulrika Carlander; Karolinska Institutet.; Karolinska Institutet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : To predict the toxicity of nanoparticles (1-100 nm), it is crucial to understand their biokinetics i.e. how they are taken up, distributed, dissolved and removed from the body. Such information can be gained from biodistribution studies in animals. READ MORE

  5. 5. Hepatic Disposition of Drugs and the Utility of Mechanistic Modelling and Simulation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Erik Sjögren; Hans Lennernäs; Scott Obach; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hepatic disposition; pharmacokinetics; mechanistic modelling; drug-drug interactions; enzyme kinetics; Vmax; Km; CLint; carrier-mediated transport; active transport; modelling; in vitro-in vivo extrapolation; physiologically based pharmacokinetic model; optimal experimental design; experimental optimization; data analysis optimization; PHARMACY; FARMACI; PHARMACY Biopharmacy; FARMACI Biofarmaci; Biopharmaceutics; Biofarmaci;

    Abstract : The elimination of drugs from the body is in many cases performed by the liver. Much could be gained if an accurate prediction of this process could be made early in the development of new drugs. However, for the elimination to occur, the drug molecule needs first to get inside the liver cell. READ MORE