Search for dissertations about: "physiologically based toxicokinetic model"

Showing result 1 - 5 of 8 swedish dissertations containing the words physiologically based toxicokinetic model.

2. 1. Physiologically based pharmacokinetic modeling in risk assessment - Development of Bayesian population methods

   Author : Fredrik Jonsson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; methyl chloride; dichloromethane; toluene; styrene; uncertainty; intra- individual variability; risk assessment; physiologically based modeling; Markov chain Monte Carlo; PBPK; Bayesian; population modeling; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Biopharmaceutics; biofarmaci;

   Abstract : In risk assessment of risk chemicals, variability in susceptibility in the population is an important aspect. The health hazard of a pollutant is related to the internal exposure to the chemical, i.e. the target dose, rather than the external exposure. READ MORE

4. 2. Physiologically Based Pharmacometric Models for Colistin and the Immune Response to Bacterial Infection

   Author : Salim Bouchene; Mats O. Karlsson; Wilhelm Huisinga; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBPK model; endotoxin; colistin; WBPBPK-PD; CMS; inflammation; tissue distribution; Kp; predictions in tissue; interspecies scaling;

   Abstract : Antibiotic treatment failure might be due to bacterial resistance or suboptimal exposure at target site and there is a lack of knowledge on the interaction between antimicrobial pharmacodynamics (PD) and the immune response to bacterial infections. Therefore, it is crucial to develop tools to increase the understanding of drug disposition to better evaluate antibiotic candidates in drug development and to elucidate the role of the immune system in bacterial infections. READ MORE

5. 3. Computational methods for assessing chemical risk : focusing on toxicokinetic modelling in zebrafish (danio rerio)

   Author : Ioana C. Chelcea; Patrik L. Andersson; Timo Hamers; Jessica Legradi; Stefan Örn; Carolina Vogs; Nynke Kramer; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; PBTK; Toxicokinetics; Endocrine disruptors; bisphenols; zebrafish; embryo; Toxicology; toxikologi;

   Abstract : New chemicals are constantly produced and large data gaps exist on hazards of currently used industrial chemicals, stressing the need for rapid, ethically sound and cost-efficient hazard assessment methods. Traditional methods for effect assessment based on animal testing, do not meet these requirements and thus the toxicology field has been moving towards the development of new approach methodologies which include in vitro approaches but also computational methods. READ MORE

6. 4. Improved scientific basis for human health risk assessment factors by toxicokinetic population modeling

   Author : Anna-Karin Mörk; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Exposure limits or guidelines are derived to protect humans from adverse effects caused by exposure to chemical substances in the environment or at the workplace. The internal dose of a chemical is determined by toxicokinetic (TK) processes such as uptake, distribution and elimination, and is closely related to the risk of adversity. READ MORE

7. 5. Ethers as gasoline additives : toxicokinetics and acute effects in humans

   Author : Annsofi Nihlén; Karolinska Institutet; Karolinska Institutet; []
   Keywords : acute effects; biological monitoring; ethyl tertiary-butyl ether; ETBE; man; methyl tertiary-butyl ether; MTBE; oxygenate; petrol; physiologically based toxicokinetic model; PBTK; PBPK; tertiary-butyl alcohol; TBA; toxicokinetics;

   Abstract : Ethers or other oxygen-containing compounds are used as replacements for lead in gasoline and to ensure complete combustion. Methyl tertiary-butyl ether (MTBE) is already in use world-wide and ethyl tertiary-butyl ether (ETBE) may be used increasingly in the future. READ MORE