Search for dissertations about: "pigment epithelium-derived factor"

Showing result 1 - 5 of 6 swedish dissertations containing the words pigment epithelium-derived factor.

2. 1. Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor

   Author : Sofia Halin; Anders Bergh; Pernilla Wikström; Stina Rudolfsson; Carl-Henrik Heldin; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; angiogenesis; castration therapy; microenvironment; stroma; tumor-associated macrophages; pigment epithelium-derived factor; PEDF; vasculature; Pathology; Patologi; patologi; Pathology;

   Abstract : BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed. READ MORE

4. 2. Regulation of Hematopoietic Stem Cells

   Author : Emma Rörby; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; hematopoietic stem cells; hematopoietic stem cell expansion; cord blood; transforming growth factor beta; Smad signaling; pigment epithelium derived factor; CD9;

   Abstract : This thesis is about the regulation of hematopoietic stem cells (HSCs) that represent rare cells residing in the bone marrow (BM) of adults. They are multipotent cells that have the capacity to differentiate to all mature cells of the blood system and have the capacity to self-renew, i.e. generate new HSCs. READ MORE

5. 3. Inner ear proteomics and barriers : Clinical and experimental findings

   Author : Jesper Edvardsson Rasmussen; Göran Laurell; Per Olof Eriksson; Helge Rask-Andersen; Jonas Bergquist; Måns Magnusson; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vestibular schwannoma; Hearing loss; Inner ear; Proteome; Perilymph; Endolymph; Furosemide; NKCC1; Fetuin-A; Complement component factor-H realted protein 2; CFHR2; Inflammation; MRI; Oto-Rhino-Laryngology; Oto-rhino-laryngologi; Medical Cell Biology; Medicinsk cellbiologi;

   Abstract : Hearing is important in many aspects of life, including communication, assessing one’s surroundings, entertainment and social interaction. Hearing loss is common and according to the Global Burden of Disease Study, 5% of the global population require hearing rehabilitation (1). READ MORE

6. 4. Pathways that govern hematopoietic stem cell fate

   Author : Matilda Billing; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : hematopoies; Hematopoietic stem cell; TGF beta; Smad signaling; GATA2; p57;

   Abstract : Hematopoietic stem cells (HSCs) compose a rare population of undifferentiated cells, residing in the bone marrow of adult individuals, ensuring life-long maintenance and replenishment of the blood system. This fantastic achievement is possible owing to two special characteristics of the HSCs: their ability to make copies of themselves (self-renew), and their capacity to differentiate to all lineages of the blood system. READ MORE

7. 5. Investigating mechanisms of angiogenesis in health and disease using zebrafish models

   Author : Zaheer Ali; Lasse D. Jensen; Neil Lagali; Massimo Santoro; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Angiogenesis, the growth of blood vessels from an existing vasculature, can occur by sprouting from preexisting vessels or by vessel splitting (intussusception). Pathological angiogenesis drives choroidal neovascularization (CNV) in age related macular degeneration (AMD) which is commonly restricted under the retinal pigment epithelium (RPE), called occult CNV, but may also involve vessels penetrating through the RPE into the sub-retinal space. READ MORE