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Showing result 1 - 5 of 45 swedish dissertations matching the above criteria.

2. 1. Construction of force measuring optical tweezers instrumentation and investigations of biophysical properties of bacterial adhesion organelles

   Author : Magnus Andersson; Ove Axner; Lene Broeng Oddershede; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; optical tweezers; biological physics; unfolding; Escherichia coli; force measurements; energy landscape; dynamic force spectroscopy; manipulation; polymers; pili; Physics; Fysik;

   Abstract : Optical tweezers are a technique in which microscopic-sized particles, including living cells and bacteria, can be non-intrusively trapped with high accuracy solely using focused light. The technique has therefore become a powerful tool in the field of biophysics. READ MORE

4. 2. The mechanics of adhesion polymers and their role in bacterial attachment

   Author : Johan Zakrisson; Magnus Andersson; Ramser Kerstin; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Pili; optical tweezers; bacterial adhesion; fimbriae; uncoiling;

   Abstract : Bacterial resistance to antibiotics is increasing at a high rate in both developing and developed countries. To circumvent the problem of drug-resistant bacterial pathogens, we need to develop new effective methods, substances, and materials that can disarm and prevent them from causing infections. READ MORE

5. 3. Synthesis and biological evaluation of Bicyclic β-Lactams and 2-Pyridinones : Pilicides Targeting Pilus Biogenesis in Pathogenic Bacteria

   Author : Hans Emtenäs; Ulf Nilsson; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; β-lactam; 2-pyridinone; 2-pyridone; Meldrum’s acid; Δ2-thiazoline; solid-phase synthesis; microwave assisted synthesis; antibacterial; pili; pilicide; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Abstract : New methods have been developed for the synthesis of bicyclic β-lactams and 2-pyridinones by combining acyl Meldrum’s acids and Δ2-thiazolines. The 2-pyridinones were synthesised both in solution using conventional heating or microwave assisted heating as well as by solid supported chemistry. READ MORE

6. 4. Peptidomimetics based on ring-fused 2-pyridones : probing pilicide function in uropathogenic E. coli and identification of Aβ-peptide aggregation inhibitors

   Author : Veronica Åberg; Fredrik Almqvist; Jan Kihlberg; Morten Grötli; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; 2-pyridone; peptidomimetic; antibacterial; pili; Escherichia coli; virulence; amyloid; Alzheimer’s.; Organic chemistry; Organisk kemi;

   Abstract : This thesis describes the synthesis and biological evaluation of highly substituted, ring-fused 2-pyridones. The utility of the bicyclic 2-pyridones to gain fundamental insights into the disease processes of bacterial infections and Alzheimer’s disease has been investigated. READ MORE

7. 5. Synthesis of substituted Ring-Fused 2-Pyridones and applications in chemical biology

   Author : Christoffer Bengtsson; Fredrik Almqvist; Paul Helquist; Umeå universitet; []
   Keywords : Synthesis; 2-pyridone; 2-thiazoline; cross coupling; pili; curli; antibacterial; organisk kemi; Organic Chemistry;

   Abstract : Antibiotics have been extensively used to treat bacterial infections since Alexander Fleming’s discovery of penicillin 1928. Disease causing microbes that have become resistant to antibiotic drug therapy are an increasing public health problem. READ MORE