Search for dissertations about: "piperidine"
Showing result 11 - 15 of 15 swedish dissertations containing the word piperidine.
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11. Synthesis, Pharmacological Characterization and QSAR Modelling of 4-Phenylpiperidines and 4-Phenylpiperazines Effects on the dopaminergic neurotransmission in vivo
Abstract : The endogenous neurotransmitter dopamine (DA) is involved in several functions that are controlled from the central nervous system (CNS), for example behaviour, memory, cognition and reward. A disturbed dopaminergic neurotransmission may lead to many severe conditions, such as schizophrenia, attention deficit hyperactivity disorder (ADHD) or Parkinson's disease (PD). READ MORE
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12. Conformationally Constrained Nucleosides : Design, Synthesis, and Biochemical Evaluation of Modified Antisense Oligonucleotides
Abstract : This thesis is concerned with synthesis, structure and biochemical analysis of chemically modified oligonucleotides with potential therapeutic applications. The three types of chemical modifications described here are: (a) A North-East locked 1',2'-azetidine nucleoside (b) A North locked 2',4'-cyanomethylene bridged nucleoside and (c) A 2',4'-aza-ENA-T nucleoside. READ MORE
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13. Synthesis of Novel Inhibitors of IdeS, a Bacterial Cysteine Protease Including Studies of Stereoselective Reductive Aminations
Abstract : Abstract The cysteine protease IdeS is an IgG degrading enzyme secreted by the bacterium Streptococcus pyogenes to evade the human immune system. In this thesis several inhibitors of IdeS have been synthesized and evaluated. Such inhibitors should be highly useful when elucidating the detailed mechanism of IdeS action. READ MORE
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14. Design, synthesis and evaluation of bacterial sialic acid uptake inhibitors
Abstract : Antibiotic resistance is a major threat for our society and finding novel antibacterial therapies is of greatimportance. In this thesis, we investigate bacterial sialic acid uptake inhibitors as a novel antibacterial approach.Bacteria do not biosynthesise sialic acid and therefore harvest it from the host. READ MORE
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15. Mechanical Pulp Based Nano-ligno-cellulose : Production, Characterisation and their Effect on Paper Properties
Abstract : Almost all research on biorefinery concepts are based on chemical pulping processes and ways of utilising lignin, hemicelluloses and extractives as well as a part of the remaining cellulose for production of nano materials in order to create more valuable products than today. Within the Forest as a Resource (FORE) research program at FSCN we are utilising the whole chain of unit processes from forestry to final products as paper and board, where the pulping process research focus on high yield process as TMP and CTMP. READ MORE