Search for dissertations about: "pituitary, mice"

Showing result 1 - 5 of 33 swedish dissertations containing the words pituitary, mice.

  2. 1. Prolactin and growth hormone in breast cancer. Studies of human breast cancer and transgenic tumor models

    Author : Maria Gebre-Medhin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prolactin; growth hormone; breast cancer; transgenic mice; estrogen receptor; insulin-like growth factor; insulin-like growth factor-I receptor;

    Abstract : Prolactin (PRL) and growth hormone (GH) are two related pituitary peptide hormones of importance during normal mammary gland development. Furthermore, their involvement in development and growth of malignant mammary tumors has been suggested by several investigators. READ MORE

  4. 2. Pituitary regulation of plasma lipoprotein metabolism and intestinal cholesterol absorption

    Author : Manuela Matasconi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Increased levels of plasma cholesterol are associated with a higher risk to develop atherosclerosis, the leading cause of death in Western societies. The major part of cholesterol in human blood is transported within low-density lipoproteins (LDL-C) that bind to specific cell surface receptors (LDLRs). READ MORE

  5. 3. Prevention of type 1 diabetes mellitus in experimental studies

    Author : Maria Holstad; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Cytokines; inducible nitric oxide synthase; nitric oxide; NOD mice; pancreatic islets; prolactin; syngeneic islet transplantation; tumour necrosis factor alpha; type 1 diabetes mellitus; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Abstract : The aim of the study was to examine the immune response and different immunoprotective strategies in experimental type 1 diabetes mellitus. The autoimmune destruction of the insulin-producing pancreatic β-cells that leads to type 1 diabetes is complex and incompletely understood. READ MORE

  6. 4. LXR regulation of hepatic gene expression and pituitary dependent hormones

    Author : Pia Kotokorpi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Liver X receptor; growth hormone; gene regulation; metabolism; hepatocyte; hepatic steatosis; species differences;

    Abstract : The liver X receptors (LXRs) are ligand activated transcription factors involved in the regulation of metabolic genes. LXRs are considered potential drug targets to treat metabolic disorders, however, unwanted side effects, as revealed from rodent studies, include increased lipogenesis in the liver and increased plasma triglyceride levels. READ MORE

  7. 5. Anatomical studies of the dopamine system in the hypothalamus and the pituitary gland

    Author : Arash Hellysaz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The hypothalamus is a small, evolutionarily conserved brain region, necessary for our survival as individuals and as a species. It collects various sensory inputs, process them to maintain homeostasis and to overcome stressors, and generates outputs that affect the autonomic nervous system, the endocrine system and somatomotor behaviors. READ MORE