Search for dissertations about: "pivotal role"

Showing result 1 - 5 of 250 swedish dissertations containing the words pivotal role.

  2. 1. Role of MYCN in retinoblastoma : From carcinogenesis to tumor progression

    Author : Hanzhao Zhang; Finn Hallböök; Johan Holmberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MYCN; retinoblastoma; RNA sequencing; cancer; avian; E2F; carcinogenesis; Developmental Neurosciences; Medicinsk utvecklings- och neurobiologi;

    Abstract : Retinoblastoma, a pediatric malignancy of the retina, is primarily driven by the bi-allelic inactivation of the RB1gene. However, a subset of cases are characterized by proficient RB1 functions but with MYCN copy number mutations, suggesting an alternative oncogenic mechanism in the absence of RB1 mutations. READ MORE

  4. 2. Proinflammatory factor mediated lymphocyte activation-the pivotal role of leukotriene B4

    Author : Anquan Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Epstein-Barr virus (EBV) is ubiquitous in the human population. More than 90% of the individuals are virus carriers. The outcome of the first encounter with the virus is highly variable. It can occur unnoticed, but if infection is delayed until adolescence it causes the infectious mononucleosis syndrome in about half of the cases. READ MORE

  5. 3. Pivotal role of the nuclear receptor PPARgamma in colon epithelial cells

    Author : Emmelie Å Jansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : When symbiosis between the residential intestinal flora and the epithelial cells of the gastrointestinal tract is broken one endpoint may be chronic inflammation, e.g. Inflammatory Bowel Disease (IBD). The disruption of the epithelial lining elicits activation of NF-kappaB and secretion of potent inflammatory mediators. READ MORE

  6. 4. Role of SOCS proteins during mycobacterial infections

    Author : Berit Carow; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mycobacterium tuberculosis is the world’s most successful bacterial killer. During infection, mycobacteria reside inside host cells encapsulated within a granuloma structure in the latent, asymptomatic phase of infection. Only 10% of latently infected develop active, infectious tuberculosis months or years after the initial infection. READ MORE

  7. 5. Role of water channels in kidney and lung

    Author : Yanhong Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Aquaporins (AQPs) are membrane proteins that function as water channels facilitating a rapid and regulated transport of water across cell membranes. AQPs in kidney and lung play pivotal roles for the regulation of water homeostasis. READ MORE