Search for dissertations about: "placental alkaline phosphatase"

Found 5 swedish dissertations containing the words placental alkaline phosphatase.

  2. 1. Human intestinal alkaline phosphatase : tissue expression and serum levels

    Author : Ulla Domar; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Human alkaline phosphatase; intestinal alkaline phosphatase; blood; blood group; lipid; monoclonal antibody; immunohistochemistry; liver; kidney; pancreas; liver disease; inflammatory bowel disease;

    Abstract : Human alkaline phosphatase (ALP) comprises four isozymes, viz liver/bone/ kidney or tissue unspecific (AP), intestinal (LAP), placental (PLAP) and germ cell or PLAP-like alkaline phosphatase, with their main expression in specific tissues as indicated by their names. The isozymes are coded by different genes, but they are closely related, with more than 50% amino acid sequence homologies. READ MORE

  4. 2. The significance of placental and placental-like alkaline phosphatases in tumor biology and their potential use in clinical practice

    Author : Annika Jeppsson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alkaline phosphatase; seminoma; eutopic; gynaecological tumors; immunolocalization;

    Abstract : Placental alkaline phosphatase (PLAP) is a membrane bound enzyme normally synthesized by the syncytiotrophoblasts in the human placenta. Recent studies have indicated that trace amounts of placental-like alkaline phosphatases also are present in several normal organs like testes and endocervix. READ MORE

  5. 3. Strategies to improve cancer radioimmunotargeting

    Author : Anders Ullén; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; : cancer; monoclonal antibody; antiidiotypic antibody; radioimmunotargeting; placental alkaline phosphatase; cytokeratin; BIAcore.;

    Abstract : Radioimmunotherapy (RIT) and radioimmunolocalisation (RIL) are developing and promising technologies to diagnose and treat tumours by use of radiolabelled antibodies targeting tumour specific antigens. The major reason why RIL and RIT not are efficient enough, is the comparatively low accumulation of radiolabelled antibodies in the tumours. READ MORE

  6. 4. Structural / functional studies on human alkaline phosphatases

    Author : Alexey Kozlenkov; Jose-Luis Millan; Hans Jörnvall; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; mutagenesis; enzyme kinetics; computer modeling; crystallography; natural substrates; uncompetitive inhibition; isozymes; gene families; Biomedicin; Microbiology; Mikrobiologi; medicinsk genetik; Medical Genetics;

    Abstract : The recent elucidation of the three-dimensional structure of human placental alkaline phosphatase (PLAP) has enabled me to perform structural studies aimed at characterizing the properties of human PLAP and tissue-nonspecific AP (TNAP) as paradigms for mammalian APs in general, using site-directed mutagenesis, protein expression, kinetic analysis and computer modeling. In Paper I, we found that a single critical E429G substitution explains the difference in stability and kinetics between the common allelic variants of PLAP and the D allozyme. READ MORE

  7. 5. Recombinant antibodies and tumor targeting

    Author : Ali Sheikholvaezin; Torgny Stigbrand; Gregory P Adams; Umeå universitet; []
    Keywords : immunologi; Immunology;

    Abstract : Different antibody derived constructs are rapidly advancing as putative tools for treatment of malignant diseases. Antibody engineering has added significant new technologies to modify size, affinities, solubility, stability and biodistribution properties for immunoconjugates. READ MORE