Search for dissertations about: "plaque instability"

Showing result 1 - 5 of 13 swedish dissertations containing the words plaque instability.

  2. 1. Cell death in atherosclerosis

    Author : Milita Crisby; Karolinska Institutet; Karolinska Institutet; []
    Keywords : atherosclerosis; carotid artery stenosis; ischemic stroke; apoptosis; necrosis; lipid peroxidation; plaque stability; pravastatin; inflammation; 27-[alpha]-hydroxylase;

    Abstract : Rupture of atherosclerotic lesions is recognized as the major cause of acute cerebrovascular and coronary syndromes. The characteristics of the typical vulnerable plaque include increased inflammatory cells at the shoulder region, a large lipid core, a thin fibrous cap with few collagen fibers and smooth muscle cells. READ MORE

  4. 2. Improving stroke risk prediction and individualised treatment in carotid atherosclerosis

    Author : Eva Karlöf; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Unstable carotid atherosclerosis causes stroke, but methods to identify patients and lesions at risk are lacking. Currently, this risk estimation is based on measurements of stenosis and neurological symptoms, which determines the therapy of either medical treatment with or without carotid endarterectomy. READ MORE

  5. 3. Linking quantitative radiology to molecular mechanism for improved vascular disease therapy selection and follow-up

    Author : Andrew J Buckler; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Objective: Therapeutic advancements in atherosclerotic cardiovascular disease have improved the prevention of ischemic stroke and myocardial infarction. However, diagnostic methods for atherosclerotic plaque phenotyping to aid individualized therapy are lacking. READ MORE

  6. 4. The immune response in atherosclerosis and acute coronary syndromes

    Author : Giuseppina Caligiuri; Karolinska Institutet; Karolinska Institutet; []
    Keywords : atherosclerosis; angina pectoris; myocardial infarction; endothelin; lymphocytes; T-cell receptor; antigens; hypercholesterolemia; mice;

    Abstract : The immune system is involved in the process of atherogenesis from the earliest steps of plaque formation, throughout the progression to the mature plaque, and finally in plaque complication and clinical manifestation of plaque instability. The present study has explored the role of specific immunity in relation to clinical instability of human coronary atherosclerosis and in experimental models of atherogenesis. READ MORE

  7. 5. Vascular repair mechanisms : experimental, physiological and clinical studies

    Author : Anton Razuvajev; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cardiovascular disease is the leading cause of global mortality and physical disability mainly due to the complications of atherothrombosis such as myocardial infarction or stroke. Surgical treatment directed to prevent this conditions is limited by the extensive healing response, intimal hyperplasia. READ MORE