Search for dissertations about: "plasmacytoid dendritic cell"

Showing result 11 - 15 of 34 swedish dissertations containing the words plasmacytoid dendritic cell.

  2. 11. The activation and regulation of plasmacytoid dendritic cells in SLE : and possible therapeutic interventions

    Author : Karin Hjorton; Lars Rönnblom; Maija-Leena Eloranta; Hans Carlsten; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLE; pDCs; NK cells; interferon; autoantibodies; immune complex; hydroxychloroquine; IRAK4 inhibition;

    Abstract : Systemic Lupus Erythematosus (SLE) is an autoimmune disease, characterized by the presence of anti-nuclear antibodies and the formation of nucleic acid containing immune complexes (ICs), which can cause organ damage by deposition in tissues. ICs strongly trigger the plasmacytoid dendritic cells (pDCs) to produce interferon (IFN)-α, which potently activates the immune system. READ MORE

  4. 12. Cardiovascular Disease and Immune Mechanisms in Systemic Lupus Erythematosus

    Author : Dag Leonard; Lars Rönnblom; Gunnel Nordmark; Maija-Leena Eloranta; Søren Jacobsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic Lupus Erythematosus; Cardiovascular Disease; Intima-Media Thickness; STAT4; IRF8; Interferon-α; Plasmacytoid dendritic cell; GM-CSF; IL-3; Medicin; Medicine; Genetics; Genetik; Immunologi; Immunology;

    Abstract : Systemic lupus erythematosus (SLE) is an autoimmune, inflammatory disease characterized by autoantibody production and an activated type I interferon system. Cardiovascular disease (CVD) is as a major cause of morbidity and mortality. The aim of this thesis was to identify genetic risk factors for CVD in SLE. READ MORE

  5. 13. T cell responses and NK cell function in experimental autoimmune diabetes

    Author : Håkan Hall; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The immune system is regulated by several complex mechanisms to maintain self tolerance and prevent autoimmune diseases. However, genetic as well as environmental factors can increase the risk of breaking self tolerance. Autoimmune diabetes is a polygenic disorder characterized by the selective destruction of pancreatic beta cells. READ MORE

  6. 14. On the role of dendritic cells in HIV-1 infection

    Author : Anna Smed Sörensen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dendritic cell; plasmacytoid; myeloid; HIV-1; cytokines; co-stimulation; transmission; antigen presentation; apoptotic cells; MuLV;

    Abstract : Dendritic cells (DCs) are antigen-presenting cells with the capacity to initiate primary T cell responses against pathogens such as HIV-1. In addition, DCs express the receptors required for HIV-1 infection and as DCs are prevalent in the mucosa, they encounter the virus early after sexual transmission. READ MORE

  7. 15. Initiation of Autoimmunity in Experimental Autoimmune Encephalomyelitis

    Author : Magnus Isaksson; Anna Lobell; Olle Kämpe; William Agace; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Autoimmunity; Cytokines; Dendritic cells; DNA vaccination; EAE; Innate immunity; T helper cells; Toll-like receptors; Type I interferons; Molekylär medicin; Molecular Medicine;

    Abstract : The events that trigger an autoimmune disease remain largely unknown. To study these events animal models are necessary because symptoms of autoimmune diseases are preceded by a long asymptomatic period in humans. READ MORE