Search for dissertations about: "plasmid"

Showing result 16 - 20 of 200 swedish dissertations containing the word plasmid.

  2. 16. Protein-Polymer Interaction and Association in Aqueous Solution

    Author : Malin Jönsson; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Physical chemistry; Fysikalisk kemi; Makromolekylär kemi; Macromolecular chemistry; enzymologi; Proteiner; enzymology; Proteins; Aqueous two-phase systems; Monte Carlo Simulations; hydrophobic effect; surface hydrophobicity; plasmid DNA; Protein; polymer;

    Abstract : The aim of this thesis has been to study protein-polymer interaction and association. Two different techniques were used; Monte Carlo simulations were combined with partitioning in polymeric aqueous two-phase systems. Monte Carlo simulations have been used to evaluate the hydrophobic interaction in electrolyte solution. READ MORE

  4. 17. Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action

    Author : Manuela Terrinoni; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vaccine development; plasmid maintenance; Gram-negative bacteria; ; essential genes; complementation; Cholera Toxin; adjuvanticity; NF-kB; mmCT; Gram-negative bacteria;

    Abstract : Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis spans several areas that are important for future development of mucosal vaccines. READ MORE

  5. 18. Induction of t-cell responses against PSA by plasmid DNA immunization

    Author : Maxim Pavlenko; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Prostate-specific antigen; DNA vaccine; cytotoxic T lymphocytes;

    Abstract : This thesis is focused on using plasmid DNA encoding human prostate-specific antigen (PSA) for immunotherapy of prostate cancer. PSA is a secreted serine protease, which is produced almost exclusively by prostate epithelial cells. READ MORE

  6. 19. Myocardial angiogenesis induced by plasmid VEGF-A165 gene transfer : experimental and clinical studies

    Author : Nondita Sarkar; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Coronary artery disease; vascular endothelial growth factor; therapeutic angiogenesis; gene transfer; plasmid DNA; gene expression;

    Abstract : New therapeutic options have emerged for patients with medically intractable angina who are not candidates for conventional revascularisation techniques, from increasing understanding of the biology of vessel formation and how different angiogenic growth factors participate in the process. Administration of vascular endothelial growth factor-A165 (VEGF-A165), a key regulator of vessel growth, has been shown to augment myocardial collateral growth. READ MORE

  7. 20. Concepts in DNA immunization overcoming viral diversity and enhancing plasmid immunogenicity

    Author : Erik Rollman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV; DNA-vaccine; gp 160; GM-CSF; HPV 16 L OBS I; MuLV; prime-boost;

    Abstract : On April 23, 1984, the prominent scientist Robert Gallo held a historical press conference at the Department of Health and Human Services, Washington D.C., USA. He announced that his laboratory at the National Institutes of Health had over the last months isolated a retrovirus named Human T-cell Leukemia Virus type III (HTLV-III). READ MORE