Search for dissertations about: "plasminogen activation"

Showing result 16 - 20 of 48 swedish dissertations containing the words plasminogen activation.

  2. 16. Systemic inflammatory activation during cardiac Surgery. Influence of cardiopulmonary bypass management and patient factors

    Author : Martin Westerberg; Göteborgs universitet; []
    Keywords : cardiopulmonary bypass; inflammatory response; coagulation; CABG; cardiotomy suction; cytokines;

    Abstract : Cardiac surgery with cardiopulmonary bypass is accompanied by a prominent systemic inflammatory and hemostatic activation, which may contribute to postoperative complications. Aims: To investigate if selection of cardiopulmonary bypass (CPB) system and management of cardiotomy suction (CTS) and mediastinal shed blood (MSB) affect systemic inflammatory response. READ MORE

  4. 17. Regulation of plasminogen activator inhibitor-1 : role of triglyceride-rich lipoproteins, fatty acids and fibrate compounds

    Author : Lennart Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : plasminogen activator inhibitor-1; coronary heart disease; endothelial cells; very low density lipoprotein VLDL ; 4G 5G polymorphism; VLDL response element; fibrate compounds; VLDL receptor; stroke;

    Abstract : Impaired fibrinolytic function secondary to elevated plasma plasminogen activator inhibitor-1 (PAI-1) activity is associated with atherothrombotic disease, in particular coronary heart disease. Both environmental and genetic factors contribute to determine plasma PAI-1 levels and PAI-1 production in vivo. READ MORE

  5. 18. Effects of Biomechanical Stress on Gene Regulation in Vascular Cells

    Author : Maria Carlström; Göteborgs universitet; []
    Keywords : shear stress; intraluminal pressure; endothelium; gene expression; DNA microarray; real-time RT-PCR; reference genes; smooth muscle cells; P2 receptors; TNF-alpha; urokinase-type plasminogen activator;

    Abstract : The vascular vessel wall is constantly exposed to biomechanical forces, such as shear and tensile stress. Biomechanical forces are important for several physiological and pathological processes and have been shown to regulate a number of fundamental vascular functions, such as vascular tone and remodeling processes. READ MORE

  6. 19. Aspects on sepsis : treatment and markers

    Author : Anna Gustafsson; Malmö högskola; []
    Keywords : antimicrobial peptides; cytokines; lipoteichoic acid; lipopolysaccharide; soluble urokinase plasminogen activator receptor; sepsis;

    Abstract : Sepsis is one of the greatest challenges in critical care medicine today, while the treatment of sepsis and evaluation of its severity is complicated. The first part of this thesis presents two approaches on the use of antimicrobial peptides in sepsis treatment, relying on both soluble and immobilized peptides. READ MORE

  7. 20. Bacterial interaction with the fibrinolytic system and extracellular matrix

    Author : Thomas Herrman Eberhard; Karolinska Institutet; Karolinska Institutet; []
    Keywords : plasminogen; extracellular matrix; basement membrane; virulence factors; fibronectin; vitronectin; collagen; Haemophilus influenzae Neisseria meningitidis Streptococcus pneumoniae;

    Abstract : Bacterial infection of host organisms is a state of complex interaction between the parasite and the host. Two critical steps in the infectious process are: Adhesion to the epithelial surfaces and penetration of tissue barriers to gain entrance to tissues and into the circulation. These two steps have been the subjects of this thesis. READ MORE